OBJECTIVE:To probe into the clinical efficacy of prescription for strengthening resistance

tonifying spleen and detoxicating in the treatment of cancer-related fatigue induced by chemotherapy for colorectal cancer

so as to analyze its effects on gastrointestinal motility disorder

vascular endothelial growth factor（VEGF） and cyclooxygenase-2（COX-2） and human soluble intercellular adhesion molecules-1（s ICAM-1） levels.METHODS:90 patients with cancer-related fatigue induced by chemotherapy for colorectal cancer admitted into the First People ’s Hospital of Nantong from Jan.2017 to Mar.2019 were selected and divided into observation group and control group via random number table

with 45 cases in each group.Both groups were given chemotherapy

while the observation group was treated with prescription for strengthening resistance

tonifying spleen and detoxicating on that basis.After two continuous courses of treatment

the scores of cancer-related fatigue

gastrointestinal function

VEGF

COX-2

s ICAM-1 levels

changes of living quality and body mass were analyzed and compared between two groups.RESULTS:After treatment

the body fatigue and total fatigue scores of observation group were significantly lower than those of the control group

with statistically significant differences（P < 0.05）;while there was no statistical significance in difference in emotional fatigue and cognitive fatigue scores between two groups（P > 0.05）.The incidence of gastrointestinal adverse drug reactions of observation group was significantly lower than that of control group

with statistically significant differences（P<0.05）.After treatment

the VEGF

COX-2 and s ICAM-1 levels of observation group were significantly lower than those of the control group;the total improvement rate of living quality and body mass were significantly higher than those of the control group

with statistically significant differences（P < 0.05）.CONCLUSIONS:The efficacy of prescription for strengthening resistance

tonifying spleen and detoxicating in the treatment of cancer-related fatigue induced by chemotherapy for colorectal cancer is remarkable

which can significantly relieve body fatigue

improve gastrointestinal motility disorder

reduce VEGF

COX-2 and s ICAM-1 levels

promote living quality and body mass.