OBJECTIVE:To probe into the clinical effects of Chaihu Shugan powder combined with methimazole in the treatment of liver stagnation hyperthyroidism.METHODS:Totally 96 patients with liver stagnation hyperthyroidism admitted into Xi’an Hospital of Traditional Chinese Medicine from Jan.2018 to Jan.2019 were extracted to be divided into the control group and the study group via the random number table

with 48 cases in each group.Patients in the control group were treated with Methimazole tablets alone

while the study group received Chaihu Shugan powder on the basis of the control group.Differences in clinical efficacy

traditional Chinese medicine syndrome score and thyroid function indexes of two groups were compared.And the incidence of adverse drug reactions were recorded.RESULTS:The total clinical effective rate in the study group was 93.75%（45/48）

significantly higher than that in the control group 77.08%（37/48）

the difference was statistically significant（P < 0.05）.After treatment

the traditional Chinese medicine syndrome score in both groups decreased significantly

and the study group was significantly lower than the control group

with statistically significant differences（P<0.05）.After treatment

the levels of FT3

FT4 and TSH in two groups decreased significantly

and the study group was significantly lower than the control group

with statistically significant differences（P<0.05）.The incidence of adverse drug reactions in the study group was 6.25%（3/48）

significantly lower than that in the control group 20.83%（10/48）

and the difference was statistically significant（P < 0.05）.CONCLUSIONS:The efficacy of Chaihu Shugan powder combined with methimazole in the treatment of liver stagnation hyperthyroidism is significant

which can promote the recovery of thyroid function with higher safety.