OBJECTIVE:Based on the population pharmacokinetic model of of amisulpride in Chinese patients with schizophrenia

to predict the steady-state blood concentration of amisulpride in patients administrated by different medication regimens

and implement individualized dosing regimen design.METHODS:110 amisulpride blood concentration values of 55 patients were retrospectively collected

the established population pharmacokinetic model of amisulpride was adopted to estimate individual pharmacokinetic parameters through the first blood concentration value

so as to predict the follow-up blood concentration value and evaluate the accuracy of model prediction by comparing the real measured value and predicted value

and Monte Carlo method was used to simulate the steady-state drug concentration range of amisulpride under different medication regimens.RESULTS:The median of error between the predicted blood concentration and real blood concentration was 2.51 ng/ml

with the average prediction error was2.78 ng/ml

the root-mean-square error was 75.8 ng/ml

which indicated the prediction model had good predictability and accuracy.There were significant differences in the steady-state trough concentration of amisulpride at different daily doses.The steady-state trough concentration increased with the increasing of daily dose;when the daily dose exceeds600 mg

the trough concentration of amisulpride will usually exceed the upper limit of recommended treatment range（320 ng/ml）;at the same daily dose

the dosing interval was 24 h

the lowest concentration of trough concentration fluctuated the most

with the administration frequency increased

the trough concentration also increased and the concentration fluctuation became smaller.CONCLUSIONS:Based on the population pharmacokinetic model

the individual drug concentration range can be accurately predicted through limited blood sampling points

the frequency and dosage of administration are the main factors affecting the blood concentration of amisulpride.