OBJECTIVE: To probe into the categories and characteristics of drugs leading to drug-induced liver injury（ DILI）

so as to provide references for clinical rational drug use.METHODS: Totally 656 patients with DILI admitted into Wangjing Hospital

China Academy of Chinese Medical Sciences from Jan.2010 to Jun.2019 were extracted.Statistical analysis was performed on clinical data of patients.RESULTS: Of the 656 patients with DILI

59.0%（ 387 cases） was male

41.0%（ 269 cases） was female

and more male than female.Among the primary diseases of DILI

infectious diseases

gastrointestinal diseases

cardiovascular diseases

skin diseases and rheumatism ranked the top 5.The drug combination of Chinese and Western medicine resulted in 91.5%（ 600 cases） of DILI

and8.5%（ 56 cases） of DILI caused by Western medicine alone

including Chinese herbal medicine

Chinese patent medicine

anti-infective drugs

anti-tumor drugs

hormone drugs

cardiovascular drugs and digestive drugs.CONCLUSIONS: In this study

the incidence of DILI in male patients is relatively high.Chinese herbal medicine and Chinese patent medicine

anti-infective drugs

anti-tumor drugs

hormonal drugs

cardiovascular drugs and digestive drugs can cause DILI

and clinical attention should be paid to prevent the occurrence of adverse drug reactions.