OBJECTIVE: To investigate the laws and characteristics of adverse drug reactions（ ADR） induced by bevacizumab injection

and to provide evidence for rational drug use.METHODS: Patients treated with bevacizumab were collected from the Fourth Medical Center of PLA General Hospital from Sept.2016 to Dec.2019.A total of 117 patients who met the inclusion criteria were enrolled

including 65 male patients and 52 female patients.The admission records were collected to summarize and analyze the primary disease

gender

age and severity grade of ADR.RESULTS: Of the 117 patients received bevacizumab injection

75 cases had ADR mentioned in the instructions for bevacizumab injection

and 39 cases had ADR that was highly correlated with bevacizumab injection

excluding the combination of drug factors.The main ADR of bevacizumab injection were hypertension（ 18 cases

the incidence rate was 15.38%）

gastrointestinal discomfort（ 15 cases

the incidence rate was 12.82%）

allergy（ 7 cases

the incidence rate was 5.98%）

hemorrhage（ 6 cases

the incidence rate was 5.13%） and proteinuria（ 2 cases

the incidence rate was 1.71%）.No fatal adverse drug reactions occured.CONCLUSIONS: ADR induced by bevacizumab injection is relatively mild

yet the characteristics of ADR induced by bevacizumab injection should be understand in clinical application

so as to exclude the high-risk population that may have severe ADR induced by bevacizumab injection

and the common ADR should be closely monitored to ensure timely and effective treatment.