OBJECTIVE: Taking cardiovascular and internal medicine-neurology drugs of our hospital as an example

to investigate the application of original drugs and generic drugs after the implementation of "4 + 7 Cities"group procurement of drugs

so as to provide data support for promoting the application of generic drugs.METHODS:The application data of the original drugs and generic drugs in Guangdong Second Provincial General Hospital（ hereinafter referred to as "our hospital"） from Apr.to Sept.2019 were extracted through the drug information management system.A total of 10 kinds of cardiovascular drugs

antidepressants

antipsychotics and antiviral drug were selected to compare the price ratio of original drugs to generic drugs

the consumption sum

the potential cost savings of replacing the original drugs

and the consumption amount.The standard unit of the purchase price（ DDDc）was standardized.In addition

the quantity of prescriptions

the number of users and the incidence of adverse drug reactions of original and generic drugs were compared.RESULTS: From Apr.to Sept.2019

the average amount of original drugs used in our hospital was 23.67%（ 50 190/212 005）

and that of the generic drugs was 76.33%（ 161 815/212 005）.The average consumption sum of the original drug was 51.57%（ 2 563 302.29 yuan/4 970 824.95 yuan）

and that of the generic drug was 48.43%（ 2 407 522.66 yuan/4 970 824.95 yuan）.Among the original drugs

Irbesartan hydrochlorothiazide tablets（ 12 290

24.49%） took the largest proportion of consumption amount

and Clopidogrel bisulfate tablets（ 999 988.50 yuan

39.01%） took the largest proportion of consumption sum.Among the generic drugs

Atorvastatin calcium tablets（ 61 524

38.02%） took the largest proportion of consumption amount

and Clopidogrel bisulfate tablets（ 1 149 306.06 yuan

47.74%） took the largest proportion of consumption sum.The average value of DDDc of 10 original drugs was 13.71

while that of generic drugs was 2.95.The total potential cost savings of generic drugs replacing the original drugs was 1 686 199.20 yuan

the cost saving rate was 65.78%.The DDDc of olanzapine was 70.57

while that of generic drugs was 11.06.The prescription amount of generic drugs was basically the same as that of the original drugs

and the number of users was significantly higher than that of the original drugs.There was no significant difference in the incidence of adverse drug reactions between the generic drugs and the original drugs.CONCLUSIONS: After the implementation of "4 + 7 Cities"group procurement of drugs

the consumption amount and consumption sum of 10 generic drugs in our hospital have increased

and the cost saving rate of generic drugs replacing the original drugs is relatively high

which can save a lot of drug costs.Generic drugs do not increase the quantity of prescriptions and the risk of adverse reactions

are more easily accepted by patients

and have a higher value for clinical promotion and application.