OBJECTIVE: To investigate the application status of glaucoma treatment drugs in 114 grade Ⅲ level A hospitals in China from 2015 to 2017

and to explore the development trend of glaucoma drug therapy in China

so as to provide reference for clinical rational drug use.METHODS: Medication data of patients diagnosed with glaucoma or ocular hypertension in outpatient ophthalmology and department of ENT in 114 hospitals were extracted to analyze and evaluate the application of glaucoma drugs

defined daily dose system（ DDDs）

defined daily cost（ DDC）

annual growth rate and drugs contraindicated for glaucoma.RESULTS: The consumption amount of traditional Chinese medicines and β-adrenergic receptor antagonists took the lead

with high levels of clinical confidence.The DDDs and DDC of various drugs were relatively stable but fluctuated

among which the DDDs of compound drug eye drops showed the trend of slow increase year by year

while the DDC showed the trend of slow decrease year by year.In the real world

there were cases of glaucoma patients using drugs that were contraindicated for glaucoma.CONCLUSIONS: The overall use of clinical glaucoma drugs is rationale

yet it is necessary to further optimize the use of drugs contraindicated for glaucoma in patients with glaucoma.