奥扎格雷钠注射液治疗急性血栓性脑梗死的快速卫生技术评估

李超; 杨子贤; 罗太敏; 李可欣; 张田; 李婷; 裴艺芳; 谭玲

doi:10.14009/j.issn.1672-2124.2020.07.018

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奥扎格雷钠注射液治疗急性血栓性脑梗死的快速卫生技术评估

用药评价 | 更新时间：2022-10-08

- 奥扎格雷钠注射液治疗急性血栓性脑梗死的快速卫生技术评估
- Rapid Health Technology Assessment of Ozagrelay Sodium Injection for Acute Cerebral Infarction
- 中国医院用药评价与分析 2020年20卷第7期页码：836-839
- 作者机构：
  
  1. 北京医院药学部/国家老年医学中心/中国医学科学院老年医学研究院
  2. 北京医院临床试验研究中心/国家老年医学中心
- 作者简介：
- 基金信息：
  
  “国家重大新药创制”科技重大专项（No.2017zx09101001）
- DOI：10.14009/j.issn.1672-2124.2020.07.018
  中图分类号： R743.3
- 纸质出版日期：2020，
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[1]李超,杨子贤,罗太敏,李可欣,张田,李婷,裴艺芳,谭玲.奥扎格雷钠注射液治疗急性血栓性脑梗死的快速卫生技术评估[J].中国医院用药评价与分析,2020,20(07):836-839+844.

LI Chao, YANG Zixian, LUO Taimin, et al. Rapid Health Technology Assessment of Ozagrelay Sodium Injection for Acute Cerebral Infarction[J]. 2020,20(7):836-839.
[1]李超,杨子贤,罗太敏,李可欣,张田,李婷,裴艺芳,谭玲.奥扎格雷钠注射液治疗急性血栓性脑梗死的快速卫生技术评估[J].中国医院用药评价与分析,2020,20(07):836-839+844. DOI： 10.14009/j.issn.1672-2124.2020.07.018.

LI Chao, YANG Zixian, LUO Taimin, et al. Rapid Health Technology Assessment of Ozagrelay Sodium Injection for Acute Cerebral Infarction[J]. 2020,20(7):836-839. DOI： 10.14009/j.issn.1672-2124.2020.07.018.

摘要

目的:基于快速卫生技术评估（health technology assessment

HTA）方法

评价奥扎格雷钠注射液治疗急性血栓性脑梗死的有效性、安全性和经济性。方法:系统检索PubMed、the Cochrane Library、EMBase、中国知网、万方数据库和中国生物医学文献数据库等数据库

查询奥扎格雷钠注射液治疗急性血栓性脑梗死的荟萃分析（Meta分析）/系统评价及药物经济学研究

由2组评价者根据纳入与排除标准独立筛选文献、提取资料

经过汇总数据后

采用定性描述的方法对结果进行定性分析。结果:共纳入0篇HTA报告

18篇Meta分析

14篇药物经济学研究。现有证据显示

患有急性脑梗死的患者

使用奥扎格雷钠注射液单药治疗

或使用奥扎格雷钠注射液与其他药物（如注射用尤瑞克林、灯盏细辛注射液、舒血宁注射液、灯盏花素注射液、巴曲酶注射液、依达拉奉注射液、血栓通注射液、苦碟子注射液、盐酸川芎嗪注射液、长春西汀注射液、丹红注射液及疏血通注射液）联合治疗

均能够显著提高临床疗效

显著改善神经功能缺损情况

患者均未出现严重的不良反应

安全性较好。经济性方面

奥扎格雷钠注射液与阿魏酸钠注射液、依达拉奉注射液、脑得生胶囊、银杏叶提取物注射液以及马来酸桂哌奇特注射液联合应用较奥扎格雷钠注射液单药治疗或其他单药治疗更为经济;但是

奥扎格雷钠注射液单药治疗与疏血通注射液、前列地尔注射液及依达拉奉注射液单药治疗比较

后者更具有经济性。结论:奥扎格雷钠注射液单药治疗或联合其他药物治疗急性脑梗死具有良好的有效性、安全性

但是奥扎格雷钠注射液单药治疗并不具有经济性

需联合应用其他药物。

Abstract

OBJECTIVE: To evaluate the effectiveness

safety and and economy of ozagrel sodium injection in the treatment of acute cerebral infarction based on rapid health technology assessment（ HTA）.METHODS: PubMed

the Cochrane Library

EMBase

CNKI

Wanfang database and CBM were systematically retrieved to collect the Metaanalysis/systematic review and pharmacoeconomic study of ozagrel sodium injection in the treatment of acute cerebral infarction.Two groups of evaluators independently screened the literature and extracted the related data according to the inclusion and exclusion criteria.After summarizing the data

the results were qualitatively analyzed by using qualitative description method.RESULTS: A total of 0 HTA reports

18 Meta-analyses and 14 pharmacoeconomic studies were included.Existing evidence suggested that for patients with acute cerebral infarction

the monotherapy with ozagrel sodium injection or with combination therapy with other drugs（ eureklin for injection

breviscapine injection

Shuxuening injection

breviscapine injection

batroxobin injection

edaravone injection

Xueshuantong injection

Kudiezi injection

Chuanxiong hydrochloride injection

vinpocetine injection

Danhong injection and Shuxuetong injection） can significantly improve the clinical efficacy and significantly improve the nerve function defect.None of the patients had severe adverse drug reactions and the safety was higher.Economically

the combination of ozagrelay sodium injection with sodium ferulate injection

edaravone injection

Naodesheng capsule

extract of ginkgo biloba injection and cinepazide maleate injection was more economical than monotherapy with ozagrel sodium injection or other monotherapy.However

monotherapy with sodium ozagrel injection was more economical than monotherapy with Shuxuetong injection

alprostadil injection and edaravone injection.CONCLUSIONS: Ozagrelay sodium injection as monotherapy or in combination with other drugs has significant efficacy and safety in the treatment of acute cerebral infarction

but monotherapy with ozagrelay sodium injection is not economical and requires the combination of other drugs.

关键词

奥扎格雷钠卫生技术评估有效性安全性经济性

Keywords

Ozagrel sodiumHealth technology assessmentEffectivenessSafetyEconomy

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