OBJECTIVE: To probe into the clinical efficacy of leuprorelin acetate microspheres sustained release for injection combined with drospirenone and ethinylestradiol tablets long-term sequential therapy in improving recurrence of stage Ⅲ-Ⅳ ovarian endometriosis after laparoscopic conservative surgery

so as to provide evidence for clinical treatment.METHODS: Totally 76 patients with ovarian endometriosis treated by laparoscopic conservative surgery in Obstetrics and Gynecology department of Beijing Tongren Hospital from Jan.2016 to Jan.2018 were extracted.According to the 1996 r-AFS criteria

all the patients were classified as stage Ⅲ-Ⅳ endometriosis.And the postoperative outpatient department was followed up regularly.All patients were randomly divided into the study group（ received leuprorelin acetate microspheres sustained release for injection after surgery and continued with long-term sequential drospirenone and ethinylestradiol tablets therapy） and the control group（ received leuprorelin acetate microspheres sustained release for injection after surgery） by lottery

with 38 cases in each group.The total subjective symptom score of two groups was calculated before surgery and after surgery of 24 months.The recurrence time and recurrence rate of two groups were compared.RESULTS: The subjective symptom score of observation groups was（ 0.94±0.59） scores

significantly lower than that of the control group（ 2.13 ± 0.67） scores

the difference was statistically significant（ P < 0.05）.In the observation group

there was only one patient with recurrence

the recurrence time was 34 months after the surgery

and the cumulative recurrence rate was 2.6%.In the control group

5 patients had recurrence

the average recurrence time was 18 months after surgery

and the cumulative recurrence rate was 13.1%.The postoperative recurrence rate of two groups was statistically significant（ P<0.05）.CONCLUSIONS:Ⅲ-Ⅳ period ovary endometriosis after laparoscopic conservative surgery

drospirenone and ethinylestradiol tablets longterm sequential therapy can alleviating the clinical symptoms

effectively reduce the long-term recurrence rate

delay the time of disease recurrence

and has certain clinical application value.