OBJECTIVE: To investigate the pharmacokinetics of single oral Terbinafine dispersible tablets in healthy volunteers in China.METHODS: Twenty-four healthy male subjects were randomly divided into two groups

and the test preparation（ Terbinafine hydrochloride dispersible tablets） or the reference preparation（ Terbinafine hydrochloride tablets） was administered orally in a single dose.After elution for 1 week

cross-dose was performed.The blood drug concentration was determined by HPLC

and the main pharmacokinetic parameters and relative bioavailability of two drugs were calculated.RESULTS: After oral administration of the test or reference preparation

the main pharmacokinetic parameters of terbinafine in the plasma of the subjects were as follows

T

max

was（ 1.545 ±0.999） h and（ 1.636 ± 0.978） h

and C

max

was（ 925.158 ± 304.526） ng/ml and（ 907.765 ± 355.11） ng/ml

respectively.The relative bioavailability of the test preparation was 108.2 ± 27.6

which was calculated in AUC

0→∞

.CONCLUSIONS: The test preparation and reference preparation are bioequivalent in healthy volunteers.