OBJECTIVE: To prepare naloxone hydrochloride orodispersible film（ NXH-ODF） and investigate dissolution behaviors in vitro.METHODS: Solvent casting method was applied to prepare the NXH-ODF

with film appearance

thickness and disintegration time as evaluation indexes.The type and dosage of NXH-ODF film-forming materials

plasticizers

surfactants and disintegrants were screened by single factor experiments.The content uniformity and in vitro release of NXH-ODF prepared with the best prescription were investigated.RESULTS: The NXH-ODF prepared by optimal formulation（ NXH 1.8%

HPMC-E30 63.9%

propylene glycol 24.8%

CMS-Na 3.6%

tween 80 3.6%

aspartame 1.8%

lemon yellow 0.5%） could disintegrate within 40 s

the conformity of drug content was up to the standard（ A+2.2 S<15.0）

and the cumulative release in vitro at 10 min reached（ 97.44 ± 2.28） %.CONCLUSIONS: The prepared NXH-ODF has smooth appearance

rapid disintegration and significant in vitro release.