OBJECTIVE: To investigate the clinical efficacy of Levothyroxine sodium tablets in the treatment of pregnancy with hypothyroidism.METHODS: Totally 83 cases of pregnancy with hypothyroidism admitted into People’s Hospital of Zunhua from Jun.2018 to Jun.2019 were extracted to be divided into the study group（ n = 43） and the control group（ n = 40） via the random number table.The control group was treated with Thyroid tablets

while the study group received Levothyroxine sodium tablets for 3 months.Thyroid function

lipid metabolism and glucose metabolism

folic acid（ FA）

vitamin B

12

( VitB

12

) and homocysteine（ Hcy） levels

pregnancy outcomes and adverse reactions of two groups were observed.RESULTS: After treatment

the levels of free triiodothyronine and free tetraiodothyroxine in the study group were significantly higher than those in the control group

and the levels of thyroid stimulating hormone were significantly lower than the control group; after treatment

the levels of total cholesterol

triglycerides and low-density lipoprotein cholesterol in the study group were significantly lower than those in the control group

and the levels of high-density lipoprotein cholesterol were significantly higher than the control group; after treatment

the fasting blood glucose

fasting insulin and insulin resistance index of the study group were significantly lower than those of the control group; after treatment

the serum FA and VitB

12

levels in the study group were significantly higher than those in the control group

and the Hcy levels were significantly lower than the control group

the differences were statistically significant（ P

<

0.05）.The incidence of cesarean section

premature delivery and abortion

fetal distress and low birth weight were significantly lower in the study group than in the control group

and the differences were statistically significant（ P

<

0.05）.No significant adverse drug reactions were observed in both groups.CONCLUSIONS: Levothyroxine sodium tablets in the treatment of pregnancy with hypothyroidism can effectively improve the thyroid function of patients

regulate glucose and lipid metabolism

decrease the incidence of adverse pregnancy outcomes

and have higher safety.