Cytochrome P450（ CYP450） enzyme is a general term for a series of heme-thiolate proteins that play an important role in the metabolic process. CYP450 enzyme is involved in about 90% of drug metabolism

and it is widely used as a key enzyme related to the metabolism of exogenous chemical substances.CYP450 enzyme is related to the metabolism of various procarcinogens and is closely related to the mechanism of action of chemotherapeutic drugs.CYP450 enzyme activity can be induced or inhibited by a variety of drug effects to enhance or inhibit enzyme activity.The action of most cancer chemotherapeutic agents requires the metabolism of CYP450 enzymes

and these enzymes may be induced or inhibited when anti-tumor traditional Chinese medicine injections are used in combination with chemotherapeutic agents

resulting in the enhancement or reduction of the clinical therapeutic effect of anti-tumor agents.Therefore

it is crucial to understand the effect of anti-tumor traditional Chinese medicine injections on CYP450 enzyme for the clinical treatment of tumors.This thesis takes basic experiments as an entry point

reviews the metabolism of CYP450 enzyme by anti-tumor traditional Chinese medicine injections

and explores the research status of the effects of traditional Chinese medicine injections on CYP450 enzyme activity.