OBJECTIVE: To investigate the characteristics and laws of adverse drug reaction（ ADR） in children in Children’s Hospital of Soochow University（ hereinafter referred to as "our hospital"）

so as to provide reference for children’s safe medication in clinic. METHODS: Retrospective analysis method was adopted

statistical analysis was conducted on 927 reports of ADR collected in our hospital from 2017 to 2018

including gender

age

route of administration

primary disease

type of drugs involved

ADR involvement of organs and（ or） systems

clinical manifestations and clinical outcomes. RESULTS: Of the 927 children who developed ADR

623 cases were male（ 67. 21%） and 304 cases were female（ 32. 79%）. There were more infants and young children

with a total of579 cases（ 62. 46%）. ADR caused by intravenous administration was the most

totally 607 cases（ 65. 48%）

including 346 infants and young children（ 37. 32%）. Respiratory system drugs caused the most ADR

totally 588 cases（ 63. 43%）

and the primary disease of infants and young children who developed ADR was mainly respiratory disease. The number of ADR cases caused by chemical drugs ranked first

with a total of 796 cases（ 85. 87%）. There were 974 case-times of ADR involving organs and（ or） systems

mainly involving skin and its accessories（ 632 casetimes

64. 89%）

and the clinical manifestations of infants and young children were mostly skin rash. The clinical outcome of ADR was good and there were no deaths. CONCLUSIONS: In clinical practice

it is necessary to strengthen the monitoring and reporting of ADR in children

so as to promote rational drug use in children and further reduce and prevent the occurrence of ADR.