OBJECTIVE: To investigate the clinical application of national key monitoring drugs in Jianhu Hospital Affiliated to Nantong University（ hereinafter referred to as "the hospital"）

so as to provide reference for further improving the clinical application of key monitoring drugs. METHODS: Interventions were performed in the hospital by using a series of assessment

audit

review and early warning measures. Statistical analysis was conducted on consumption sum

defined daily dose system（ DDDs）

application rate and rationality

standardability of key monitoring drugs before intervention（ the 4 th quarter of 2018） and after intervention（ the 4 th quarter of 2019）.RESULTS: After intervention

the proportion of consumption sum of key monitoring drugs to the total drugs decreased from 4. 38%（ 2 025 737. 50 yuan/46 237 198. 20 yuan） before intervention to 2. 75%（ 1 451 480. 20 yuan/52 795 033. 57 yuan） after intervention

DDDs decreased by 4 730. 5 year on year（ 18 355. 0 before intervention and13 624. 5 after intervention）

among which drugs for promoting blood circulation and removing blood stasis showed the greatest decrease. The application rate of antibiotics in inpatients decreased from 25. 5%（ 436/1 713） before intervention to 7. 2%（ 154/2 152） after intervention. There was significant improvement in inappropriate indications

with the proportion decreased from 20. 4%（ 89/436） before intervention 7. 1%（ 11/154） after intervention.CONCLUSIONS: The comprehensive intervention measures of the hospital are feasible and effective

and can ensure the safety

effectiveness and economy of the clinical application of national key monitoring drugs.