OBJECTIVE: To probe into the effects of PDCA cycles on implementation of antimicrobial stewardship program（ ASP） led by clinical pharmacists in a grade Ⅲ

class A general hospital（ hereinafter referred to as "the hospital"）. METHODS: Based on the strategy of ASP

comprehensive intervention measures were implemented in the comprehensive department ward of the hospital

including first-time premedication review

medication review with intervention and feedback

patients with >10 d duration of antibiotics. Training for clinicians and education for patients on medication were performed. The ASP was optimized by using PDCA cycles management

the proportion of consumption sum of antibiotics to the total drugs

application rate of antibiotics in inpatients

use intensity of antibiotics in inpatients and special application grade antibiotics in inpatients

and microbiological test specimen submission rates for patients receiving antimicrobial therapy were compared before PDCA cycle（ from Jul. to Oct.2018） and after PDCA cycle（ from Nov. 2018 to Oct. 2019）. RESULTS: After the adoption of ASP and continuous optimization of intervention measures through PDCA cycles

the proportion of consumption sum of antibiotics to the total drugs in inpatients decreased from 25. 71% to 17. 87%

and the application rate of antibiotics in inpatients decreased from 50. 46% to 40. 53%

both of which showed the significant decrease trend

with statistically significant differences compared with before PDCA cycle（ P<0. 05）. The use intensity of antibiotics in inpatients decreased from37. 34 DDDs/（ 100 people·d） to 27. 68 DDDs/（ 100 people·d）

and the use intensity of special application grade antibiotics in inpatients decreased from 10. 94 DDDs/（ 100 people·d） to 6. 00 DDDs/（ 100 people·d）. The rate of microbiological test specimen submission rates for patients receiving antimicrobial therapy increased from 48. 19% to66. 36%

showing the increasing trend

and the difference was statistically significant compared with before PDCA cycle（ P< 0. 05）. CONCLUSIONS: In this study

the clinical pharmacists lead the ASP and adopt PDCA cycles to continuously optimize the ASP intervention measures and improve the rational application level of antibiotics in the comprehensive ward of the hospital’s cadre comprehensive department. However

there are still some problems

which need to be further improved in the future.