OBJECTIVE: To investigate the application status and treatment process of antibiotics in chronic obstructive pulmonary disease（ COPD）. METHODS: Retrospective analysis was conduced on clinical data of 983 patients with COPD from the Fourth Affiliated Hospital of Nanjing Medical University（ hereinafter referred to as "our hospital"） from 2017 to 2019. Categories

consumption sum

drug utilization index（ DUI） and daily drug cost（ DDC） were statistically analyzed. RESULTS: During the treatment

the application rate of antibiotics in 983 patients was 100%

among which 735 patients were given one kind of antibiotics

187 patients were given two kinds of antibiotics

52 patients were given three kinds of antibiotics and 9 patients were given four kinds of antibiotics. The average number of antibiotics used in each patient was 2. 35±0. 68. The average consumption sum of antibiotics used was（ 1 573. 9±17. 52） yuan. The third generation cephalosporins and quinolones accounted for 33. 7%（ n = 331） and25. 7%（ n = 253） of the total antibiotics used in our hospital. DUIs in the range of 1. 0 ± 0. 1 were respectively levofloxacin

cefotaxime

cefoperazone sulbactam and fluconazole. The top five drugs ranked by DDC were respectively teicoplanin

imipenemcilastatin

piperacillintazobactam

cefoxitin and cefotaxime. CONCLUSIONS: The application of antibiotics in the treatment of COPD in our hospital is basically reasonable

but there is still room for improvement

and the management system of application of antibiotics in the hospital needs to be further improved.