OBJECTIVE: To research the molecular mechanism of Shaofu Zhuyu decoction in the treatment of primary dysmenorrhea based on Integrated Pharmacology Platform V2. 0. METHODS: To collect the traditional Chinese medicine components of Shaofu Zhuyu decoction and its related targets and dysmenorrhea disease targets through the Integrated Pharmacology Platform V2. 0

so as to analyze the interaction between drug targets and disease targets

to establish a "Chinese medicine-disease core target"network and finally construct a "Chinese medicine-componenttarget-pathway"multidimensional network through the TCM related network mining module. RESULTS: A total of 352 chemical components and 1 903 drug targets of 9 categories of Chinese herbs in Shaofu Zhuyu decoction were collected

15 disease targets of dysmenorrhea were obtained after screening. Results of drug and disease target analysis showed that there were 3 common targets（ PPARG

PTGS2 and CYP17 A1）; results of visual network analysis indicated that quercetin

isorhamnetin and eugenol in Shaofu Zhuyu decoction may participate in pathways of dopamine receptor

eNOS activation and VEGFA-VEGFR2 pathway by acting on targets of ESR1

CNR1 and CALM1

so that play the role in the treatment of primary dysmenorrhea. CONCLUSIONS: The core target network and multidimensional visual network of Shaofu Zhuyu decoction and primary dysmenorrhea are constructed Based on the Integrated Pharmacology Platform V2. 0

which provides an important reference for the research of Shaofu Zhuyu decoction in the treatment of primary dysmenorrhea

and also provides a theoretical basis for clinical application.