OBJECTIVE: To probe into the clinical efficacy of Qingresanjie capsule combined with ganciclovir ophthalmic gel in the treatment of epidemic keratoconjunctivitis. METHODS: 90 patients with epidemic keratoconjunctivitis admitted into the Fifth People’s Hospital of Chengdu from Apr. 2018 to Apr. 2019 were selected and divided into control group and observation group via random number table

with 45 cases in each group. The control group was treated with ganciclovir ophthalmic gel

while the observation group was given Qingresanjie capsule combined with ganciclovir ophthalmic gel

both groups were treated for 14 days. The clinical efficacy

TCM syndrome scores

corneal subepithelial infiltrate scores（ CSIS）

eyesight and tear lactoferrin（ LF）

total protein（ TP） and lysozyme（ LZM） levels of the two groups before and after treatment were observed

the incidences of adverse drug reactions of the two groups were recorded and compared. RESULTS: The total clinical effective rate of observation group was 97. 78%（ 44/45）

which was significantly higher than that of the control group（ 86. 67%

39/45）

with statistically significant difference（ P<0. 05）. After treatment

the eyesight levels of both groups had been improved

the CSIS and various TCM syndrome scores were significantly lower than those of before treatment; after treatment

the eyesight of observation group was significantly better than that of the control group

while the CSIS and various TCM syndrome scores were significantly lower than those of the control group

with statistically significant differences（ P <0. 05）. After treatment

the tear LF

TP and LZM levels of both groups were significantly higher than those of before treatment

and LF

TP and LZM levels of the observation group was significantly higher than the control group

with statistically significant differences（ P<0. 05）. During treatment

the incidences of adverse drug reactions of observation group and control group were respectively 4. 44%（ 2/45） and 13. 32%（ 6/45）

the difference had no statistical significance（ P>0. 05）. CONCLUSIONS: The efficacy of Qingresanjie capsule combined with ganciclovir ophthalmic gel in the treatment of epidemic keratoconjunctivitis is remarkable

which is helpful to relieve clinical symptoms and corneal injury

improve eyesight

with good safety.