OBJECTIVE: To probe into the intervention effects of clinical pharmacists on rational application of proton pump inhibitors（PPI） in Ordos Central Hospital

so as to provide reference for further promotion of rational drug use.METHODS: Retrospective analysis was adopted

a total of 6 179 patients who were hospitalized with PPI before intervention（from May to Aug.2018） and 5 976 patients who were hospitalized with PPI after intervention（from May to Aug. 2019） were collected

the application of PPI were compared and analyzed the before and after intervention.RESULTS: Before and after intervention

there were no statistically significant differences in gender

age and department distribution of patients using PPI（P > 0. 05）. After intervention

both the total consumption sum of PPI and the consumption sum of PPI injection decreased by more than 30% compared with those before intervention

the consumption sum of PPI oral preparation in single case after intervention generally increased compared with that before intervention.The consumption sum of PPI in single case decreased from 286. 32 yuan before intervention to 203. 99 yuan

the consumption sum of PPI injection in single case decreased from 344. 98 yuan before intervention to 267. 80 yuan

and the consumption sum of PPI oral preparation in single case decreased from 93. 27 yuan before intervention to79. 42 yuan. The total DDDs of PPI and the DDDs of PPI injection decreased by 12. 05% and 30. 26%

respectively

while the DDDs of PPI oral preparation increased by 17. 61%. The per capita hospitalization cost of patients using PPI decreased from 344. 98 yuan before intervention to 267. 80 yuan

the per capita daily medication cost decreased from 62. 31 yuan before intervention to 52. 03 yuan

and the average number of treatment days decreased from 5. 54 d before intervention to 3. 86 d. The ratio of consumption sum sequencing/DDDs sequencing of PPI with oral dosage form was generally increased. The price level of most PPIs remained stable. The application rationality of PPI application before intervention was better than that before intervention. CONCLUSIONS: Rational medication management of clinical pharmacists is conducive to the rational application of PPI

which can greatly reduce the pharmaceutical cost of patients with PPI

with the value of further implementation.