OBJECTIVE: To investigate the monitoring on blood concentration of perphenazine

so as to provide references for clinical rational drug application. METHODS: Clinical data of patients taking perphenazine and monitored blood concentration in Beijing Anding Hospital Affiliated to Capital Medical University（hereinafter referred to as "our hospital"） from Jun. 2018 to Feb. 2020 were collected

including age

gender

dose

combined medication and averse drug reactions. To retrospectively analyze the correlation between patients’ blood concentration and the distribution of blood concentration of perphenazine

patients’ gender

age

dose and adverse drug reactions. RESULTS:A total of 229 case-times of monitoring data were collected from 111 patients

61 patients（54.95%） were monitored the blood concentration for only once

50 patients（45.05%） had been adjusted dosage and repeated monitoring through blood concentration monitoring; the average blood concentration of perphenazine was（2.42±2.73） ng/ml

but the individual difference was large

37.84% of patients（42 cases） were within the effective blood concentration range.There was no statistical significance in difference in the concentration of perphenazine between patients of different genders（P>0.05）; the blood concentration of perphenazine showed a trend of increasing first and then decreasing with the increasing of patients’ ages

while the difference had no statistical significance（P>0.05）; with the increase of medication dose

the blood concentration of perphenazine also increased

the difference was statistically significant（P<0.05）. CONCLUSIONS: The blood concentration of perphenazine varies greatly among individuals

the blood concentrations of children

adolescents and elderly patients are relatively lower. It is necessary to strengthen drug monitoring and formulate an individualized dosage regimen based on the measured blood concentration

to select appropriate dose to reduce the incidence of adverse drug reactions while ensure efficacy.