OBJECTIVE: To systematically evaluate the clinical effects of Jisheng Shenqi pills for diabetic nephropathy

so as to provide reference for further clinical practice. METHODS: The Cochrane Library

EMBase

PubMed

Web of Science

Allied and Complementary Medicine

CNKI

VIP database

CBM and Wanfang database were retrieved to collect the randomized controlled trial of Jisheng Shenqi pills for diabetic nephropathy（ the control group was treated with conventional treatment measures such as diet control

regular schedule and rest assurance

and infection prevention

while the study group received Jisheng Shenqi formula recipe or Jisheng Shenqi pills combined with other traditional Chinese medicine decoction and Chinese patent medicine）. The retrieval time was from the establishment of the database to Jul. 16 th

2019. The cochrane reviews handbook version 5. 1. 0 was adopted for literature quality evaluation

and the Rev Man 5. 3 software was used for Meta-analysis. RESULTS: Totally 15 literature were collected.Meta analysis results showed that the effective rate of the observation group was significantly higher than that of the control group（ RR = 1. 32

95% CI = 1. 23-1. 42

P <0. 01）

and the 24 h urine protein quantification was significantly lower than that of the control group（ MD =-0. 16

95%CI =-0. 21—-0. 11

P<0. 01）

2 h postprandial blood glucose was significantly better than that of the control group（ MD =-1. 29

95% CI =-1. 62—-0. 96

P < 0. 01）

the content of glycated hemoglobin was significantly lower than that of the control group（ MD =-1. 32

95% CI =-2. 08—-0. 57

P <0. 01）

the differences were statistically significant. CONCLUSIONS: The clinical effects of Jisheng Shenqi pills for diabetic nephropathy is significant. Yet the methodological quality of the literature included in this study is relatively low

and rigorous high-quality clinical randomized controlled trials still need to be designed in the future.