OBJECTIVE: To probe into the effectiveness and economy of different types of meal and basic insulin therapy for type 2 diabetes. METHODS: Retrospective analysis was adopted

totally 216 patients with type 2 diabetes admitted into Tianjin Medical University Chu Hisen-I Memorial Hospital from Jan. 2016 to Jan. 2019 were extracted to be divided into group A（n = 56）

group B（n = 53）

group C（n = 54） and group D（n = 53） according to different treatment regimen. Group A was treated with insulin lispro + insulin glargine

group B was treated with insulin lispro +insulin detemir

group C was treated with insulin aspart+insulin detemir

and group D was treated with insulin aspart+insulin glargine. The treatment course of four groups was 2 weeks. The blood glucose level before and after treatment and clinical efficacy were compared among four groups. And the cost-effectiveness analysis was used for economic evaluation. RESULTS: The total effective rate of group A

B

C and D was 91. 07%（51/56）

84. 91%（45/53）

87. 04%（47/54） and 86. 79%（46/53）

respectively

with no statistically significant difference（P > 0. 05）. The costs of treatment regimen in group A

B

C and D were 320. 24

327. 06

331. 16 and 324. 31 yuan

respectively.The cost-effectiveness ratio of group A

B

C and D were respectively 3. 52

3. 85

3. 80 and 3. 74

with group A having the lowest. The incremental cost-effectiveness ratio of group B

C and D were respectively-1. 11

-2. 71 and-0. 95

and group A had more cost-effectiveness advantages. Sensitivity analysis results supported cost-effectiveness analysis results. CONCLUSIONS: From the efficacy analysis of short-term treatment

the treatment of insulin lispro combined with insulin glargine for type 2 diabetes is better.