OBJECTIVE: To probe into the efficacy of Yishenfuhuo Tongluo decoction combined with medullary core decompression in the treatment of early osteonecrosis of femoral head of qi-stagnation and blood-stasis type and its effect on patients hemorheology

bone metabolism

blood coagulation

serum transforming growth factor β1（TGF-β1） and homocysteine（Hcy）. METHODS: Totally 126 patients with early osteonecrosis of femoral head of qi-stagnation and blood-stasis type admitted into the First People’s Hospital of Tianmen from Jan. 2018 to Feb. 2019 were selected and divided into treatment group and control group via random number table

with 63 cases in each group. The treatment group was given Yishenfuhuo Tongluo decoction combined with medullary core decompression

while the control group was treated with medullary core decompressio alone. Harris score of hip joint

hemodynamic indices

bone metabolism indices [serum typeⅠprocollagen amino terminal propeptide（PⅠNP）

tartrate-resistant acid phosphatase 5 b（TRACP-5 b） and type Ⅱcarboxy terminal peptide of collagen（CTX-Ⅱ） ]

blood coagulation indices [prothrombin time（PT）

activated partial thromboplastin time（APTT）

thrombin time（TT） and fibrinogen（FIB） ]

serum TGF-β1 and Hcy levels of both groups were observed. RESULTS: At 4 weeks after surgery

the Harris scores of hip joint of both groups were significantly higher than those of 1 week before surgery

the Harris score of hip joint of the treatment group were significantly higher than those of the control group

with statistically significant differences（P<0. 05）. At 4 weeks after surgery

the whole blood high-shear viscosity

whole blood low-shear viscosity

plasma viscosity and hematocrit level of both groups were significantly lower than those of 1 week before surgery

and the hemodynamic indices of treatment group were significantly lower than those of the control group

with statistically significant differences（P<0. 05）. At 2 weeks and 4 weeks after surgery

the serum PⅠNP and TRAP-5 b levels of both groups were significantly lower than those of 1 week before surgery

while the CTX-Ⅱlevels had been significantly increased; at 4 weeks after surgery

the PⅠNP and TRAP-5 b levels of treatment group were significantly lower than those of the control group

with statistically significant differences（P < 0. 05）. At 2 weeks and 4 weeks after surgery

the serum PT

APTT and TT of both groups were significantly longer than those of 1 week before surgery

while the FIB levels had been significantly decreased; at4 weeks after surgery

the PT and APTT of treatment group were significantly longer than those of the control group

while the FIB level was significantly lower than the control group

with statistically significant differences（P<0. 05）. At2 weeks and 4 weeks after surgery

the TGF-β1 levels of both groups were significantly higher than those of 1 week before surgery

while the Hcy levels had been significantly decreased; at 4 weeks after surgery

the Hcy level of treatment group was significantly lower than that of the control group

with statistically significant differences（P < 0. 05）.CONCLUSIONS: Yishenfuhuo Tongluo decoction can reduce the blood viscosity of patients with early osteonecrosis of femoral head of qi-stagnation and blood-stasis type after surgery

relieve blood hypercoagulation

promote bone metabolism

reduce Hcy level and alleviate inflammatory reaction.