OBJECTIVE: To investigate the characteristics and regularity of adverse drug reactions（ ADR）induced by immunosuppressant and medication in related organ transplantation

so as to provide references for clinical rational medication. METHODS: Retrospectively research was adopted to analyze the immunosuppressant related ADR reports collected by ADR monitoring center of China PLA during Jan. 1 st 2009 to Jan. 1 st 2019. RESULTS: A total of4 826 cases of ADR induced by immunosuppressant were collected from 151 hospitals

with the male to female ratio was 1∶ 1; among the patients with severe ADR

the proportion of patients aged ≥60 years was higher; the occurrence time of ADR was mainly 2-< 7 days after medication; the ADR-inducing drugs were mainly involved glucocorticoids

antibodies and alkylating agents; the ADR involved organs and（ or） systems were mainly gastrointestinal system and systemic damage

the severe ADR mainly involved blood system; after treatment

4 314 patients（ 89. 39%） were cured or turned better; there were 4 deaths reported（ 1 case related to organ transplantation）. Of which 442 cases of ADR were related to medication after organ transplantation

with the male to female ratio was 2∶ 1; the occurrence time of ADR was mainly ≥15 days after medication; the ADR-inducing drugs were mainly involved calcineurin inhibitor

antibodies and Anti-metabolites/anti-proliferation; after treatment

379 patients（ 85. 75%） were cured or turned better. CONCLUSIONS: The therapeutic window of immunosuppressant is narrow

but its efficacy cannot be replaced.The clinical medication safety monitoring for patients

especially after organ transplantation

should be strengthened

timely and effective interventions should be conducted to prevent the occurrence of severe ADR as much as possible.