OBJECTIVE: To investigate the application of atomization inhalation medication for inpatients in a Grade Ⅲ Level A hospital（ hereinafter referred to as "the hospital"）

so as to provide reference for clinical rational drug use. METHODS: The hospital information system was used to extract 12 075 long-term medical orders with inpatients given drugs by atomization inhalation from Jan. to Jun. 2019. Departments

basic information of patients

drug name

usage

dosage and clinical diagnosis were collected

defined daily dose system（ DDDs）

prescription daily dose

drug utilization index（ DUI） were statistically analyzed. RESULTS: A total of 12 075 atomization inhalation medication orders were collected

including 3 209 inpatients

aged 1 d to 98 years old. The number of orders of patients over 60 years old was mostly（ 5 744 pieces

47. 57%）. There were 31 clinical departments

mainly spinal surgery

respiratory and otolaryngology. Disease diagnosis mainly based on respiratory diseases. A total of 21 kinds of drugs were enrolled

and the top 3 are budesonide suspension for inhalation

acetylcysteine solution for inhalation and ambroxol hydrochloride injection. The number of medical orders for atomized preparation was 5 443 pieces

including6 specifications

and only the DUI of acetylcysteine for inhalation was more than 1

which indicating that the daily dose of the prescription was more than the maximum daily dose specified in the drug instructions. Non-atomization preparation used for atomization was off-label drug use

and the number of medical orders was 6 632 pieces. There were 2 077 groups of drug combination. Double drug combination were mainly inhalation of budesonide suspension +acetylcysteine solution for inhalation

inhalation of budesonide suspension + inhalation of albuterol sulphate solution or terbutaline sulphate atomization

inhalation of budesonide suspension + inhalation of isopropanotropium bromide solution and inhalation of budesonide suspension + ambroxol hydrochloride injection or injection of ambroxol hydrochloride. Triple drug combination were mainly inhalation of budesonide suspension + inhalation of albuterol sulphate solution or terbutaline sulphate aerosol + inhalation of isopentropium bromide solution

and there were quadruple drug combination. The single dose range was 2-110 ml

and the average dose was（ 9. 52 ± 5. 76） ml.CONCLUSIONS: Atomization inhalation treatment is widely used in clinical practice

but there are few kinds of atomization preparations to choose. And there are some situations such as inaccurate single doses

irrational drug combination

and abuse of non-atomization preparations. It is necessary to strengthen supervision and promote the rational use of atomization inhalation medication.