OBJECTIVE: To quantitatively analyze and systematically review the effect of conventional doses of Yupingfeng powder combined with antihistamines on chronic urticaria. METHODS: Randomized controlled trials（ the intervening measure of drug combination group was conventional dose of Yupingfeng powder combined with antihistamines;the control group was given conventional dose of antihistamines alone; the antihistamines included mizolastine

ebastine

cetirizine

levocetirizine

loratadine

desloratadine citrate disodium

fexofenadine

olopatadine

acrivastine

azelastine

bepotastine besilate and desloratadine） on Yupingfeng powder combined with antihistamines in the treatment of chronic urticaria published on CNKI

CBM

VIP

Wanfang

Pub Med and EMBase from base-building to Oct. 2019 were retrieved. RevMan 5. 3 and Stata 14. 2 were adopted to conduct Meta analysis. RESULTS: A total of 28 studies were involved

including 1 422 patients. Results of Meta analysis indicated that the total effective rate of drug combination group was significantly higher than that of the control group（ OR = 3. 85

95% CI = 2. 91-5. 11

P < 0. 000 01）

the recurrence rate of drug combination group was significantly lower than that of the control group（ OR = 0. 36

95% CI =0. 27-0. 49

P < 0. 000 01）

with statistically significant differences; there was no statistical significance in difference in incidences of adverse drug reactions between two groups（ OR = 0. 79

95% CI = 0. 52-1. 20

P = 0. 27）.CONCLUSIONS: Compared with antihistamines alone

Yupingfeng powder combined with antihistamines is more effective in the treatment of chronic urticaria

with a lower recurrence rate and roughly equivalent safety.