OBJECTIVE:To probe into the efficacy of complete mesocolic excision（CME）combined with ulinastatin in treatment of right-side colon carcinoma and its effects on serum midkine（MK）and tumor specific growth factor（TSGF）.METHODS:120 patients with right-side colon carcinoma admitted into Chongming Hospital of Xinhua Hospital Affiliated to Shanghai Jiaotong University School of Medicine from Feb.2015 to Feb.2018 were selected and divided into control group and research group according to the matching principle

with 60 cases in each group.Both groups were treated with CME

on this basis

the research group was given ulinastatin for intravenous drip after surgery.The clinical efficacy

primary hepatic and renal indices[alanine aminotransferase（ALT）

aspartate aminotransferase（AST）

total bilirubin（TBIL）

creatinine and blood urea nitrogen（BUN）]

MK

TSGF

inflammatory factors[tumor necrosis factor-α（TNF-α）

interleukin-6（IL-6）and interleukin-8（IL-8）]

immunological function indices and incidences of main complications of both groups were observed.RESULTS:The postoperative food-taking time

recovery time of normal diet and hospital stay of research group were significantly shorter than those of the control group

with statistically significant differences（P

<

0.05）.At 1 day and 3 days after surgery

the ALT

AST

TBIL

creatinine and BUN levels of both groups had been significantly increased

and those of research group were significantly lower than the control group

with statistically significant differences（P

<

0.05）.After treatment

the serum MK

TSGF

TNF-α

IL-6

IL-8

CD4

+

and CD8

+

levels of both groups had been significantly decreased

and those of research group were significantly lower than the control group

with statistically significant differences（P

<

0.05）.The incidences of complication of research group and control group were respectively 26.67%（16/60）and 21.67%（13/60）

the difference had no statistical significance（P

>

0.05）.CONCLUSIONS:The efficacy of CME combined with ulinastatin in treatment of right-side colon carcinoma is remarkable

which can significantly shorten hospital stay and improve patients’prognoses

which has protection for patients’hepatic and renal function

and effectively reduce tumor related marker levels with higher safety.