OBJECTIVE: To probe into the efficacy of leonurus injection combined with oxytocin injection in the prevention of postpartum hemorrhage. METHODS: Totally 134 parturients admitted into Qinhuangdao Military Engineering Hospital from Jan. 2017 to Jun. 2018 were extracted to be divided into the control group and the observation group via different intervention methods

with 67 cases in each group. The control group was treated with oxytocin injection alone

while the observation group were divided into medium-risk group（ n = 22）

low-risk group（ n = 27） and high-risk group（ n = 18） according to the results of risk prediction on postpartum hemorrhage. After delivery

the observation group was given 2 ml of leonurus injection for intramuscular injection at gluteus maximus based on the control group; the high-risk group was given 2 ml of leonurus injection according to the bleeding situation after delivery. The postpartum hemorrhage rate

amount of bleeding

intensity of uterine contraction

coagulation function [prothrombin time（ PT）

activated partial thromboplastin time（ APTT） ]

clinical efficacy and incidence of adverse drug reactions of all groups were observed. RESULTS: The incidence of postpartum hemorrhage of observation group was 16. 41%（ 11/67）

which was significantly lower than that of the control group（ 34. 32%

23/67）

with statistically significant difference（ P < 0. 05）. During the operation

2 h and 24 h after operation

the average amount of bleeding of observation group was significantly lower than that of the control group

with statistically significant difference（ P < 0. 05）; in the comparison among observation groups

the amount of bleeding of high-risk group was the highest at each time point. At 10 min

30 min and 60 min after delivery

the average intensity of uterine contraction of observation group was significantly higher than that of the control group

with statistically significant difference（ P <0. 05）; in the comparison among observation groups

the intensity of uterine contraction of high-risk group was weaker at each time point. At before delivery and 3 days after

there were no statistical significance in the difference in APTT and PT levels between two groups（ P > 0. 05）; in the comparison among observation groups

the APTT and PT levels of high-risk group was slightly longer

while the differences between low-risk group and medium-risk group had no statistical significance（ P > 0. 05）. The total effective rate of observation group was 95. 54%（ 62/67）

which was significantly higher than that of the control group（ 77. 61%

52/67）

with statistically significant difference（ P <0. 05）. The incidences of adverse drug reactions of observation group and control group were respectively 17. 91%（ 12/67） and 26. 87%（ 18/67）

the difference had no statistical significance（ P > 0. 05）. CONCLUSIONS: The effect of leonurus injection combined with oxytocin injection in the prevention of postpartum hemorrhage is remarkable

which can significantly decrease postpartum hemorrhage rate and reduce the amount of bleeding; the intervention of leonurus injection on patients at different risk levels can enhance the intensity of uterine contraction

ensure coagulation function

reduce adverse drug reactions and improve prognosis.