dexmedetomidine on levels of nasal mucosal aquaporin（ AQP-1） and quality of life in patients undergoing nasal endoscopic surgery during perioperative period. METHODS: Totally 620 patients undergoing nasal endoscopic surgery under elective general anesthesia admitted into Children’s Hospital of Dongguan

Donghua Hospital of Dongguan and Dongguan People’s Hospital from May 2017 to May 2018 were extracted to be divided into the combination group and the control group via the random number table

with 310 cases in each group. Patients in the control group were given dexmedetomidine 0. 5 g/kg intravenously at 15 min before surgery

followed by continuous intravenous pumping at0. 4 g/（ kg·h）. And the combination group was treated with dexmedetomidine combined with hematothrombin

0. 5 μg/kg dexmedetomidine was given in intravenous infusion at 15 min before surgery

followed by continuous intravenous pumping at 0. 4 g/（ kg·h） and intramuscular injection of hematothrombin 2 KU at 30 min before surgery.Levels of serum interleukin 6（ IL-6） and interleukin 10（ IL-10） of two groups were recorded before surgery

immediately after surgery

after surgery of 1 d and after surgery of 3 d. AQP-1 level and quality of life of two groups were observed before surgery and after surgery of 2

4 and 8 weeks. Bleeding volume

surgery time

extubation time

spontaneous breathing recovery time

and incidence of of adverse drug reactions and complications of two groups were compared. RESULTS: Immediately after surgery

after surgery of 1 d and after surgery of 3 d

the levels of serum IL-6 and IL-10 in the combination group were significantly lower than those in the control group

and the differences were statistically significant（ P < 0. 05）. After surgery of 2

4 and 8 weeks

the score of Health Survey Questionnaire of the combination group was significantly higher than that of the control group

and sino-nasal outcome test-20（ SNOT-20）was significantly lower than that of the control group; after surgery of 4 and 8 weeks

the levels of mucosal AQP-1 in the combination group were significantly lower than those in the control group

and the differences were statistically significant（ P < 0. 05）. The bleeding volume of the combination group was significantly lower than that of the control group

and the surgery time was significantly shorter than that of the control group

with statistically significant differences（ P < 0. 05）. There was no significant difference in extubation time and spontaneous breathing recovery time between two groups（ P > 0. 05）. No severe complications such as respiratory depression and restlessness were observed in two groups. Three patients in the control group developed dry mouth

and two patients had dry mouth and one patient had bradycardia in the combination group. CONCLUSIONS: Hemopertase from snake venom combined with dexmedetomidine can reduce the expression of levels of mucosal AQP-1 and inflammatory factors in patients undergoing nasal endoscopic surgery during perioperative period

improve the quality of life

and has lower incidence of complications

which is worthy of promotion.