OBJECTIVE: To probe into the clinical efficacy of butylphthalide and sodium chloride injection combined with sodium ozagrel injection in the treatment of acute progressive cerebral infarction. METHODS: 116 patients with acute progressive cerebral infarction admitted into Danzhou People’s Hospital from Jun. 2017 to May2019 were retrospectively analyzed and divided into observation group and control group according to different therapeutic regimens

with 58 cases in each group. The control group was treated with sodium ozagrel injection

while the observation group was given butylphthalide and sodium chloride injection combined with sodium ozagrel injection.The clinical efficacy

differences in National Institutes of Health Stroke Scale（ NIHSS） scores

Barthel indices

changes of blood coagulation factor and incidences of adverse drug reactions of the two groups were compared.RESULTS: The total effective rate of observation group was 89. 66%（ 52/58）

which was significantly higher than that of the control group（ 74. 14%

43/58）

with statistically significant difference（ P < 0. 05）. After treatment

the NIHSS scores of both groups were significantly decreased

while the Barthel indices of both groups were significantly increased; the NIHSS score of observation group was significantly lower than that of the control group

while the Barthel index of observation group was significantly higher than that of the control group

with statistically significant differences（ P < 0. 05）. After treatment

the activated partial thromboplastin time（ APTT）

prothrombin time（ PT）and international normalized ratio（ INR） levels of both groups were significantly increased

while the fibrinogen（ FIB）level was significantly decreased; the APTT

PT and INR levels of observation group were significantly higher than those of the control group

while the FIB level of observation group was significantly lower than that of the control group

with statistically significant differences（ P < 0. 05）. The incidences of adverse drug reactions of observation group and control group were respectively 13. 79%（ 8/58） and 10. 34%（ 6/58）

the difference had no statistical significance（ P > 0. 05）. CONCLUSIONS: The clinical efficacy of butylphthalide and sodium chloride injection combined with sodium ozagrel injection in the treatment of acute progressive cerebral infarction is remarkable

which can effectively relieve the damage of neurological function and improve coagulation function.