OBJECTIVE: To probe into the effects of rifamycin sodium injection combined with linezolid injection on inflammatory response

serum procalcitonin（ PCT） and adverse drug reactions in patients with severe gram-positive coccus infection. METHODS: Totally 60 patients with severe gram-positive coccus infection admitted into Shangqiu First People’s Hospital from May 2018 to Sept. 2019 were extracted to be divided into the study group and the control group via the random number table

with 30 cases in each group. The control group was treated with linezolid injection

while the study group additionally received rifamycin sodium injection based on the control group.Differences of clinical efficacy

levels of inflammatory indexes [white blood cell count（ WBC）

high-sensitivity Creactive protein（ hs-CRP）

interleukin 1β（ IL-1β） and interleukin 10（ IL-10） ]

levels of serum PCT and adverse drug reactions of two groups were compared. RESULTS: The total effective rate in the study group was significantly higher than that in the control group [90. 00%（ 27/30） vs. 66. 67%（ 20/30） ]

and the difference was statistically significant（ P < 0. 05）. After treatment

the levels of serum WBC

CRP and IL-1β in two groups were significantly lower than those before treatment

and the levels of serum IL-10 were significantly higher than those before treatment;the levels of WBC

CRP and IL-1β in the study group were significantly lower than those in the control group

and the levels of IL-10 were significantly higher than those in the control group

differences were statistically significant（ P <0. 05）. After treatment

the levels of serum PCT of two groups was significantly lower than those before treatment

and the study group was significantly lower than the control group

with statistically significant differences（ P < 0. 05）.The incidence of adverse drug reactions in the study group and the control group were 23. 33%（ 7/30） and 26. 67%（ 8/30）

respectively

with no statistically significant difference（ P > 0. 05）. CONCLUSIONS: The clinical efficacy of rifamycin sodium injection combined with linezolid injection is remarkable

which can significantly reduce the levels of serum PCT

improve the inflammatory response of patients

relief the infection symptoms and has certain clinical application value.