尼莫地平联合神经内镜微创术治疗高血压脑出血的效果及对血清同型半胱氨酸、白细胞介素1β的影响

许西海; 王玉华; 高艳; 李爱兰; 李少泉

doi:10.14009/j.issn.1672-2124.2020.04.010

您当前的位置：

首页 >

文章列表页 >

尼莫地平联合神经内镜微创术治疗高血压脑出血的效果及对血清同型半胱氨酸、白细胞介素1β的影响

论著 | 更新时间：2022-10-08

- 尼莫地平联合神经内镜微创术治疗高血压脑出血的效果及对血清同型半胱氨酸、白细胞介素1β的影响
- Efficacy of Nimodipine Combined with Neuroendoscopic Minimally Invasive Surgery in the Treatment of Hypertensive Cerebral Hemorrhage and its Effect on Serum Homocysteine and Interleukin-1β
- 中国医院用药评价与分析 2020年20卷第4期页码：421-424
- 作者机构：
  
  1. 沧州市人民医院神经外科
  2. 沧州市中心医院静配中心
- 作者简介：
- 基金信息：
  
  河北省医学科学研究重点课题计划项目（No.20191252）
- DOI：10.14009/j.issn.1672-2124.2020.04.010
  中图分类号： R651.1
- 纸质出版日期：2020，
扫描看全文
[1]许西海,王玉华,高艳,李爱兰,李少泉.尼莫地平联合神经内镜微创术治疗高血压脑出血的效果及对血清同型半胱氨酸、白细胞介素1β的影响[J].中国医院用药评价与分析,2020,20(04):421-424.

XU Xihai, WANG Yuhua, GAO Yan, et al. Efficacy of Nimodipine Combined with Neuroendoscopic Minimally Invasive Surgery in the Treatment of Hypertensive Cerebral Hemorrhage and its Effect on Serum Homocysteine and Interleukin-1β[J]. 2020,20(4):421-424.
[1]许西海,王玉华,高艳,李爱兰,李少泉.尼莫地平联合神经内镜微创术治疗高血压脑出血的效果及对血清同型半胱氨酸、白细胞介素1β的影响[J].中国医院用药评价与分析,2020,20(04):421-424. DOI： 10.14009/j.issn.1672-2124.2020.04.010.

XU Xihai, WANG Yuhua, GAO Yan, et al. Efficacy of Nimodipine Combined with Neuroendoscopic Minimally Invasive Surgery in the Treatment of Hypertensive Cerebral Hemorrhage and its Effect on Serum Homocysteine and Interleukin-1β[J]. 2020,20(4):421-424. DOI： 10.14009/j.issn.1672-2124.2020.04.010.

摘要

目的:探讨尼莫地平联合神经内镜微创术治疗高血压脑出血的效果及对血清同型半胱氨酸（Hcy）、白细胞介素1β（IL-1β）的影响。方法:选取2015年9月至2017年9月沧州市人民医院收治的高血压脑出血患者92例

按照随机数字表法将所有患者分为手术组、联合组

每组46例。手术组患者给予神经内镜微创术

联合组患者在手术组的基础上加用尼莫地平。观察两组患者临床相关指标情况、血肿体积、水肿体积、神经功能缺损量表评分（neural function defect score

NFDS）、Hcy和IL-1β水平

并对两组患者临床疗效、治疗后1年的预后情况进行统计比较。结果:联合组患者手术时间、住院时间明显短于手术组

术中出血量明显低于手术组

血肿清除率明显高于手术组

差异均有统计学意义（P <0. 05）。治疗后

联合组患者血肿体积、水肿体积、NFDS评分、Hcy和IL-1β水平明显低于手术组

差异均有统计学意义（P <0. 05）。联合组患者的总有效率为97. 83%（45/46）

明显高于手术组的82. 61%（38/46）

差异有统计学意义（P <0. 05）。治疗后1年

联合组患者的预后较好

恢复良好患者所占比例为84. 78%（39/46）

明显高于手术组的54. 35%（25/46）

差异有统计学意义（P <0. 05）。结论:尼莫地平联合神经内镜微创术能够有效改善高血压脑出血患者神经功能恢复情况

改善患者预后

但由于样本量有限

仍需要进一步验证后推广应用。

Abstract

OBJECTIVE: To probe into the efficacy of nimodipine combined with neuroendoscopic minimally invasive surgery in the treatment of hypertensive cerebral hemorrhage and its effect on serum homocysteine（ Hcy） and interleukin-1β（ IL-1β） . METHODS: Totally 92 patients with hypertensive cerebral hemorrhage admitted into Cangzhou People ’s Hospital from Sept. 2015 to Sept. 2017 were selected and divided into operation group and combination group via random number table

with 46 cases in each group. The operation group was treated with neuroendoscopic minimally invasive surgery

while the combination group was treated with nimodipine based on the operation group. The clinical related indices

volume of hematoma

volume of edema

neural function defect score（ NFDS）

Hcy and IL-1β levels of both groups were observed

the clinical efficacy and prognosis of 1 year after treatment in the two groups were compared. RESULTS: The duration of operation and hospital stay of combination group were significantly shorter than those of the operation group

the amount of bleeding of combination group were significantly less than that of the operation group

the clearance rate of hematoma of combination group were significantly higher than that of the operation group

with statistically significant differences（ P < 0. 05）. After treatment

the volume of hematoma

volume of edema

NFDS

Hcy and IL-1β levels of combination group were significantly lower than those of the operation group

with statistically significant differences（ P < 0. 05）. The total effective rate of combination group was 97. 83%（ 45/46）

which was significantly higher than that of the operation group（ 82. 61%

38/46）

with statistically significant difference（ P < 0. 05）. At 1 year after treatment

the combination group had good prognosis; the proportion of patients who recovered well was 84. 78%（ 39/46）

which was significantly higher than that of operation group（ 54. 35%

25/46）

with statistically significant difference（ P <0. 05）. CONCLUSIONS: Nimodipine combined with neuroendoscopic minimally invasive surgery can effectively improve the recovery of neurological function and prognosis in patients with hypertensive cerebral hemorrhage

however

due to the limited sample size

it still needs further verified for popularization and application.

关键词

神经内镜微创术尼莫地平高血压脑出血同型半胱氨酸白细胞介素1β

Keywords

Neuroendoscopic minimally invasive surgeryNimodipineHypertensive intracerebral hemorrhageHomocysteineInterleukin-1β

references

查看原文

浏览量

下载量

CSCD

文章被引用时，请邮件提醒。

提交

工具集

关联资源

银杏叶胶囊联合前列地尔注射液对后循环缺血性眩晕患者脑血流和血清同型半胱氨酸、成纤维细胞生长因子21的影响

尼莫地平联合高频重复经颅磁刺激治疗皮层下非痴呆型血管性认知障碍的临床疗效研究

尼可地尔联合依那普利叶酸片用于急性ST段抬高型心肌梗死患者急诊经皮冠状动脉介入术后的疗效观察

注射用鼠神经生长因子联合奥拉西坦治疗高血压脑出血的临床研究

血清同型半胱氨酸、肿瘤标志物与转移性结直肠癌患者化疗疗效的相关性研究