OBJECTIVE: To investigate the characteristics and regularities of adverse drug reactions（ ADR）occurred in psychiatric patients

so as to provide theoretical references for clinical safe medication. METHODS: Data of ADR cases in 925 psychiatric patients reported from Jan. 2015 to Aug. 2019 were collected and analyzed in terms of patients’ general information

main suspected drugs and its classification

ADR involved organs and（ or） systems and main clinical manifestation

the causal correlation and outcomes. RESULTS: Among the 925 psychiatric patients with ADR

mostly were aged > 60（ 323 cases

34. 92%）; the primary diseases of patients were mainly schizophrenia（ 562 cases

60. 76%）. The main suspected drugs had induced 1 044 case-times of ADR

mainly concentrated in antipsychotic drugs

of which olanzapine had induced the most ADR（ 171 case-timss

16. 38%）. There were 1 072 case-times of ADR involved organs and（ or） systems

mainly involved the neurological system（ 239 case-times

22. 29%）

and the clinical manifestations were mainly extrapyramidal diseases. Of the 925 patients with ADR

587 patients turned better after treatment

including 63. 46%. CONCLUSIONS: Medication monitoring on psychiatric patients should be strengthened

dosage reduction and drug withdrawl should be timely conducted when ADR occurred to ensure safe and effective medication.