OBJECTIVE: To probe into the regularities and characteristics of adverse drug reactions（ ADR）occurred in Shenzhen Hospital of Southern Medical University（ hereinafter referred to as "our hospital"）

so as to provide references for clinical safe medication. METHODS: 221 cases of ADR monitored and reported in our hospital during 2016-2018 were collected and analyzed in terms of types of ADR

patients’ gender and age

categories of involved drugs

ADR involved organs and（ or） systems

correlation analysis and prognosis. RESULTS: During 2016-2018

the number of reported ADR in our hospital had increased year by year. Among the 221 cases of ADR

mostly were general ADR

including 137 cases（ 61. 99%）; the number of male patients（ 127 cases

57. 47%） was more than that of female patients（ 94 cases

42. 53%）; most patients were aged between > 60-70; 76 varieties of 14 categories of drugs were involved; anti-infectious drugs had induced the most ADR cases

followed by diagnostic drugs（ contrast agents）; intravenous administration was the main route inducing ADR

followed by oral administration; the ADR mainly involved skin and its accessories

followed by digestive system; there were 29 cases of severe ADR

of which 11 cases（ 37. 93%） were induced by anti-infectious drugs; of the 67 new ADR cases

24 cases were induced by anti-infectious drugs; most patients turned better after drug withdrawl and symptomatic treatment. CONCLUSIONS: The occurrence of ADR is related to multiple factors

including categories of drugs

administration routs and patients’ age

medical staff should pay attention to ADR monitoring to promote safe clinical medication.