OBJECTIVE: To investigate the application rationality and safety of ticagrelor in elderly patients with coronary heart disease in Huadong Hospital Affiliated to Fudan University（ hereinafter referred to as "this hospital"）

so as to provide reference for the rational drug use in clinic. METHODS: Retrospective investigation method was adopted

evaluation and analysis were conducted on application rationality of ticagrelor in 162 cases of elderly patients with coronary heart disease from Jun. 2018 to Sept. 2019 in this hospital. RESULTS: Of the 162 cases of elderly patients with coronary heart disease

the indications of 161 cases（ 99. 38%） met the recommendations of relevant guidelines. During the course of clinical medication

the coexistence of multiple diseases and multiple drugs were common

and the patients presented bleeding（ 36 cases

22. 22%）

elevated uric acid（ 18 cases

11. 11%）

bradycardia（ 4 cases

2. 47%） and other symptoms. The combination of ticagrelor and traditional Chinese medicines for promoting blood circulation and removing blood stasis can increase adverse drug reactions of bleeding in patients. It is recommended to strengthen clinical monitoring during medication

so as to ensure medication safety.CONCLUSIONS: Due to limited clinical experience in China and the absence of specific antagonists

the pharmacodynamics and safety of clinical application need to be further verified.