唑来膦酸注射液联合碳酸钙D<sub>3</sub>片治疗老年女性骨质疏松症的疗效观察

赵静; 邰敏歌; 苗伟; 任艳飞

doi:10.14009/j.issn.1672-2124.2020.03.013

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唑来膦酸注射液联合碳酸钙D₃片治疗老年女性骨质疏松症的疗效观察

论著 | 更新时间：2022-10-08

- 唑来膦酸注射液联合碳酸钙D₃片治疗老年女性骨质疏松症的疗效观察
- Efficacy of Zoledronic Acid Injection Combined with Calcium Carbonate D₃ Tablets in the Treatment of Osteoporosis in Elderly Women
- 中国医院用药评价与分析 2020年20卷第3期页码：308-311
- 作者机构：
  
  赤峰市医院内分泌科
- 作者简介：
- 基金信息：
- DOI：10.14009/j.issn.1672-2124.2020.03.013
  中图分类号： R580
- 纸质出版日期：2020，
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[1]赵静,邰敏歌,苗伟,任艳飞.唑来膦酸注射液联合碳酸钙D_3片治疗老年女性骨质疏松症的疗效观察[J].中国医院用药评价与分析,2020,20(03):308-311.

ZHAO Jing, TAI Minge, MIAO Wei, et al. Efficacy of Zoledronic Acid Injection Combined with Calcium Carbonate D₃ Tablets in the Treatment of Osteoporosis in Elderly Women[J]. 2020,20(3):308-311.
[1]赵静,邰敏歌,苗伟,任艳飞.唑来膦酸注射液联合碳酸钙D_3片治疗老年女性骨质疏松症的疗效观察[J].中国医院用药评价与分析,2020,20(03):308-311. DOI： 10.14009/j.issn.1672-2124.2020.03.013.

ZHAO Jing, TAI Minge, MIAO Wei, et al. Efficacy of Zoledronic Acid Injection Combined with Calcium Carbonate D₃ Tablets in the Treatment of Osteoporosis in Elderly Women[J]. 2020,20(3):308-311. DOI： 10.14009/j.issn.1672-2124.2020.03.013.

摘要

目的:探讨唑来膦酸注射液联合碳酸钙D3片治疗老年女性骨质疏松症的临床疗效。方法:以2013年1月至2018年5月赤峰市医院收治的老年女性骨质疏松症患者192例作为研究对象

采用随机数字表分为唑来膦酸组（给予唑来膦酸注射液治疗）、碳酸钙D3组（给予碳酸钙D3片治疗）及联合用药组（给予唑来膦酸注射液联合碳酸钙D3片治疗）

每组64例。比较三组患者治疗前后血磷和血钙的含量、骨密度（包括Ward三角区、股骨大转子、股骨颈和腰椎L2—4骨密度）、骨代谢相关生化指标[骨特异性碱性磷酸酶（BAP）、骨钙素（BGP）、人抗酒石酸酸性磷酸酶5b（TRAP-5b）和Ⅰ型胶原羟基端肽β降解产物（β-CTX）]含量及临床疗效的差异。结果:随着时间迁移

三组患者血磷、血钙、BAP及BGP含量

股骨大转子、股骨颈及腰椎L2—4骨密度呈显著升高趋势;而TRAP-5b、β-CTX含量呈显著降低趋势。治疗后

三组患者血磷、血钙、BAP、BGP、TRAP-5b及β-CTX含量

股骨大转子、股骨颈及腰椎L2—4骨密度的差异均有统计学意义（P<0. 05）。治疗后

联合组患者血磷、血钙、BAP及BGP含量

股骨大转子、股骨颈及腰椎L2—4骨密度明显高于唑来膦酸组和碳酸钙D3组

TRAP-5b含量明显低于唑来膦酸组和碳酸钙D3组

差异均有统计学意义（P<0. 05）。联合组患者的总有效率为92. 19%（59/64）

明显优于唑来膦酸组的79. 69%（51/64）和碳酸钙D3组的78. 13%（50/64）

差异均有统计学意义（P<0. 05）。结论:唑来膦酸注射液和碳酸钙D3片对老年女性骨质疏松症有一定的疗效

二者联合治疗的效果更好。

Abstract

OBJECTIVE: To probe into the clinical efficacy of zoledronic acid injection combined with Calcium carbonate D

tablets in the treatment of osteoporosis in elderly women. METHODS: Totally 192 elderly patients with osteoporosis admitted into Chifeng Hospital from Jan. 2013 to May 2018 were extracted to divide into the zoledronic acid injection group（ with the treatment of zoledronic acid injection）

Calcium carbonate D

tablets group（ with the treatment of Calcium carbonate D

tablets） and combination group（ with the treatment of zoledronic acid injection combined with Calcium carbonate D

tablets） via the random number table

with 64 cases in each group. The level of serum phosphorus and calcium

bone mineral density（ including the Ward triangle

the greater trochanter of femur

the neck of femur and lumbar spine L2—4 bone mineral density）

bone metabolism related biochemical indicators [bonespecific alkaline phosphatase（ BAP） and bone gla protein（ BGP）

tartrate resistant acid phosphatase 5 b（ TRAP-5 b）and type Ⅰ collagen hydroxyl terminal peptide β degradation products（ β-CTX） ] before and after treatment and the clinical efficacy of three groups were compared. RESULTS: The levels of blood phosphorus

calcium

BAP

BGP

the greater trochanter of femur

the neck of femur and lumbar spine L2—4 bone mineral density in three groups increased significantly; while the levels of TRAP-5 b and β-CTX decreased significantly. Before and after treatment

the differences in levels of serum phosphorus

calcium

BAP

BGP

TRAP-5 b

β-CTX

the greater trochanter of femur

the neck of femur and lumbar spine L2—4 bone mineral density were statistically significant（ P

0. 05）. After treatment

the levels of serum phosphorus

calcium

BAP and BGP

the greater trochanter of femur

the neck of femur and lumbar spine L2—4 bone mineral density in the combination group were significantly higher than those in the zoledronic acid injection group and the Calcium carbonate D

tablets group

and the level of TRAP-5 b was significantly lower than that in the zoledronic acid injection group and the calcium carbonate D

tablets group

with statistically significant differences（ P

0. 05）. The total effective rate in the combination group was 92. 19%（ 59/64）

significantly higher than 79. 69%（ 51/64） in the zoledronic acid injection group and 78. 13%（ 50/64） in the calcium carbonate D

tablets group

with statistically significant differences（ P

0. 05）. CONCLUSIONS: Zoledronic acid injection and calcium carbonate D

tablets have certain therapeutic effects on osteoporosis in elderly women

but the combined treatment is more effective and has clinical significance.

关键词

唑来膦酸注射液碳酸钙D3片骨质疏松症老年女性

Keywords

Zoledronic acid injectionCalcium Carbonate D3tabletsOsteoporosisElderly women

references

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唑来膦酸注射液联合碳酸钙D3片治疗老年女性骨质疏松症的疗效观察

Efficacy of Zoledronic Acid Injection Combined with Calcium Carbonate D3 Tablets in the Treatment of Osteoporosis in Elderly Women

DOI：10.14009/j.issn.1672-2124.2020.03.013

摘要

Abstract

关键词

Keywords

references

唑来膦酸注射液联合碳酸钙D₃片治疗老年女性骨质疏松症的疗效观察

Efficacy of Zoledronic Acid Injection Combined with Calcium Carbonate D₃ Tablets in the Treatment of Osteoporosis in Elderly Women