OBJECTIVE: To probe into the effects of butylphthalide and sodium chloride injection combined with citicoline sodium injection on neurological function and JAK2/STAT3 signal transduction pathway in elderly patients with cerebral infarction（ CI）. METHODS: 60 elderly patients with CI admitted into No. 909 Hospital of Joint Logistic Support Force of PLA from Mar. 2017 to May 2019 were selected and divided into observation group and control group via simple randomized grouping method

with 30 cases in each group. Both groups were given conventional treatment

on this basis

the control group was treated with citicoline sodium injection

while the observation group was given butylphthalide and sodium chloride injection combined with citicoline sodium injection. The clinical efficacy

changes in neurological function [National Institutes of Health Stroke Scale（ NIHSS） score]

activity of daily living（ Barthel index） and hemorheology indices

serum brain-derived neurotrophic factor（ BDNF）

neuron specific enolase（ NSE）

glutathione peroxidase（ GSH-Px）

total antioxidant capacity（ T-AOC） and JAK2/STAT3 signal transduction pathway related protein expression levels of the two groups before and after treatment were observed. RESULTS: The total effective rate of observation group was 90. 00%（ 27/30）

which was significantly higher than that of the control group（ 66. 67%

20/30）

with statistically significant difference（ P < 0. 05）. After treatment

the NIHSS score of observation group was significantly lower than that of the control group

while the Barthel index was significantly higher than that of the control group

with statistically significant differences（ P<0. 05）; after treatment

the plasma viscosity

whole blood viscosity

platelet aggregation rate and fibrinogen of observation group were significantly lower than those of the control group

while the serum BDNF

NGF

GSH-Px and T-AOC levels were significantly higher than those of the control group

with statistically significant differences（ P<0. 05）; after treatment

the expression levels of JAK2

P-JAK2 and P-STAT3 of observation group were significantly lower than those of the control group

with statistically significant differences（ P < 0. 05）. CONCLUSIONS: The efficacy of butylphthalide and sodium chloride injection combined with citicoline sodium injection in treatment of elderly patients with CI is remarkable

it can effectively improve patients’ neurological function and activity of daily living

which may be related that the therapeutic regimen can further improve blood rheology

relieve oxidative stress response and improve brain protection effect.