OBJECTIVE: To probe into the clinical efficacy of dermatophagoides farinae drops combined with Montelukast sodium tablets in the treatment of allergic rhinitis（ AR） in children. METHODS: Totally 238 children with AR admitted into 174 Hospital of the People’s Liberation Army from Jan. 2016 to Aug. 2018 were extracted to be divided into the control group and the study group via the random number table

with 119 cases in each group. The control group was given Montelukast sodium tablets

while the study group additionally received dermatophagoides farinae drops based on the control group. The clinical efficacy

changes in symptom scores

interleukin-4（ IL-4）

interleukin-6（ IL-6）

interleukin-17（ IL-17）

immunoglobulin E（ Ig E）

and immune-related indicators before and after treatment were observed

and the incidence of adverse drug reactions of two groups were recorded. RESULTS:The total effective rate of the study group was 91. 60%（ 109/119）

significantly higher than 71. 43%（ 85/119） of the control group

the difference was statistically significant（ P

<

0. 05）. After treatment

the symptom scores of runny nose

sneezing

nasal congestion and nasal itching in two groups were significantly lower than those before treatment

and the study group was signficantly lower than the control group

the difference was statistically significant（ P

<

0. 05）. After treatment

the levels of IL-4

IL-6

IL-17 and Ig E in two groups were significantly lower than those before treatment

and the study group was significantly lower than the control group

the difference was statistically significant（ P

<

0. 05）. After treatment

the levels of CD3

+

CD4

+

and CD4

+

/CD8

+

in two groups were significantly higher than those before treatment

and the study group was significantly higher than the control group; the levels of CD8

+

in two groups were significantly lower than those before treatment

and the study group was significantly lower than the control group

with statistically significant difference（ P

<

0. 05）. The incidences of adverse drug reactions in the study group and the control group were respectively 12. 61%（ 15/119） and 10. 08%（ 12/119）

the difference was not statistically significant（ P

>

0. 05）. CONCLUSIONS: The efficacy of dermatophagoides farinae drops combined with Montelukast sodium tablets in the treatment of AR is significant

which can effectively improve the level of inflammatory factors in children and improve immune function without increasing the incidence of adverse drug reactions.