OBJECTIVE: To probe into the application value of dexmedetomidine（ DEX） nasal drops in preoperative sedation for children with cyanotic and non-cyanotic congenital heart disease. METHODS: Totally 80 children with congenital heart disease admitted into Sichuan Mianyang 404 Hospital from Jun. 2017 to Dec. 2018 were extracted

including 40 cases of cyanotic heart disease and 40 cases of non-cyanotic congenital heart disease. All children were divided into the control group（ 0. 9% sodium chloride solution）

low-dose group（ DEX 1 μg/kg）

medium-dose group（ DEX 2 μg/kg） and high-dose group（ DEX 3 μg/kg） via the random number table

with10 cases in each group. Ramsey score（ Ramsay） and Modified Yale perioperative anxiety scale（ m YPAS） of two groups were evaluated. Heart rate（ HR） and oxygen saturation（ SPO

2

） were measured. RESULTS: The Ramsay score of cyanotic and non-cyanotic children in the low-dose

medium-dose and high-dose group was significantly higher than that of the control group

and the m YPAS score was significantly lower than that of the control group. Among them

the Ramsay score of cyanotic and non-cyanotic children in the high-dose group was significantly higher than that of lowdose and medium-dose group and m YPAS score was significantly lower than that of low-dose and medium-dose group

the differences were statistically significant（ P

<

0. 05）. Before administration and after administration of 10

20 and 30 min

there was no statistically significant difference in the levels of HR and SPO

2

among four groups of children with cyanotic heart disease（ P

>

0. 05）

and the difference in the levels of HR and SPO

2

among four groups of children with non-cyanotic heart disease was not statistically significant（ P

>

0. 05）. CONCLUSIONS: The application of DEX nasal drops is effective in preoperative sedation of children with congenital heart disease and had similar effects in cyanotic and non-cyanotic congenital heart disease.