OBJECTIVE: To probe into the efficacy of Runjiang Lige pills combined with mosapride in the treatment of diabetic gastroparesis（ DGP）（ insufficiency of stomach yin） and its effects on gastrointestinal hormones and oxidative stress reaction

so as to provide reference for clinical treatment. METHODS: Totally 117 patients with DGP（ insufficiency of stomach yin） admitted into endocrinology department of Shijiazhuang Traditional Chinese Medicine Hospital from Jan. 2018 to Oct. 2019 were extracted to be divided into the study group（ n = 63） and the control group（ n = 54） via the random number table. Patients in both groups received routine treatment. On this basis

the control group was given mosapride

while the study group was treated with Runjiang Lige pills combined with mosapride. The total course of treatment was 2 weeks. Differences of gastrointestinal hormones [motrin（ MOT）

gastrin（ GAS） ]

oxidative stress indicators [superoxide dismutase（ SOD）

reactive oxygen species（ ROS） and malondialdehyde（ MDA） ]levels and gastric emptying rate of two groups were observed before and after treatment. The clinical efficacy

incidence of adverse dug reactions and recurrence of two groups were observed. RESULTS: After treatment

the levels of MOT

GAS

SOD and gastric emptying rate in two groups were significantly higher than those before treatment

and the levels of ROS and MDA were significantly lower than those before treatment

with statistically significant differences（ P < 0. 05）. After treatment

the levels of MOT

GAS

SOD and gastric emptying rate in the study group were significantly higher than those in the control group

and the levels of ROS and MDA were significantly lower than those in the control group

with statistically significant differences（ P<0. 05）. The total effective rate in the study group was 92. 06%（ 58/63）

significantly higher than 74. 07%（ 40/54） in the control group

and the difference was statistically significant（ P < 0. 05）. During the treatment process

no significant adverse drug reactions were observed in the study group

while the levels of alanine aminotransferase increased in 2 patients in the control group. There was no recurrence in the study group

while in the control group

there were 8 cases of compound（ recurrence rate was 14. 81%）. CONCLUSIONS: The efficacy of Runjiang Lige pills combined with mosapride in the treatment of DGP（ insufficiency of stomach yin） is significant with higher safety

which can effectively promote the gastric motility and reduce oxidative stress reaction in vivo.