OBJECTIVE: To probe into the regularity of neurological adverse drug reactions induced by ertapenem

so as to provide reference for safe drug use in clinic. METHODS: Totally 6 cases of adverse drug reaction on nervous system induced by ertapenem in Peking University People’s Hospital in 2017 were summarized

analyzed and reevaluated. RESULTS: Of the 6 patients

4 were male（ 66. 67%） and 2 were female（ 33. 33%）

the male to female ratio was 2 ∶ 1. The age ranged from 55 to 92 years

with an average of（ 79. 83 ± 13. 26） years. There were4 patients with renal insufficiency（ 66. 67%）. Six patients had neurological adverse drug reactions after application of urtapenem of 2 to 5 d

all of which were manifested as mental disorders

mainly including symptoms of excitement

multilingualism

insomnia

apathy

lethargy

delirium and hallucinations. After the drug was withdrew

the symptoms were alleviated and disappeared. CONCLUSIONS: For elderly patients with renal insufficiency

special attention should be paid to the dose adjustment of ertapenem and related adverse drug reactions

so as to effectively reduce the risks to patients.