OBJECTIVE: To probe into the efficacy of isosorbide mononitrate combined with perindopril in the treatment of chronic heart failure and its effects on N-terminal B-type natriuretic peptide（ NT-proBNP）. METHODS:Totally 96 patients with chronic heart failure admitted into Fuyang Hospital

Anhui Medical University from Dec. 2017 to Dec. 2018 were extracted to be divided into the observation group and the control group via the random number table

with 48 cases in each group. Based on conventional treatment

the control group was treated with perindopril

while the observation group received isosorbide mononitrate combined with perindopril. The stroke volume（ SV）

cardiac output per minute（ CO）

left ventricular ejection fraction（ LVEF）

left ventricular end diastolic diameter（ LVEDD）

and left ventricular peak diastolic blood velocity/end diastolic peak blood velocity ratio（ E/A） of two groups were compared. The clinical efficacy and changes of plasma NT-proBNP levels were observed. RESULTS: After treatment

the levels of SV

CO

LVEF and E/A of two groups were significantly higher than those before treatment

and the level of LVEDD was significantly lower than that before treatment

and the levels of the above indicators in the observation group were significantly better than those in the control group

the differences were statistically significant（ P<0. 05）. The total effective rate in the observation group was 91. 67%（ 44/48）

significantly higher than that in the control group（ 72. 92%

35/48）

with statistically significant difference（ P < 0. 05）. After treatment

the plasma NT-proBNP levels in two groups were significantly lower than those before treatment

the observation group was significantly lower than the control group

and the differences were statistically significant（ P < 0. 05）.CONCLUSIONS: Compared with perindopril alone

isosorbide mononitrate combined with perindopril in the treatment of chronic heart failure can significantly improve patient’s cardiac function

reduce the plasma NT-proBNP levels

which is conducive to rehabilitation.