OBJECTIVE: To probe into the efficacy of phloroglucinol in treatment of gallstone complicated with choledocholithiasis after laparoscopic transcystic common bile duct exploration（ LTCBDE） and its effect on serum amylase（ AMS） and cortisol（ Cor） levels. METHODS: 160 patients with gallstone complicated with choledocholithiasis admitted into the Second Affiliated Hospital of Xingtai Medical College from Feb. 2017 to Apr. 2018 were selected and randomly divided into observation group and control group

with 80 cases in each group. The control group was given LTCBDE

while the observation group was given phloroglucino after LTCBDE. The perioperative indices

serum AMS

Cor

liver function indices [alanine aminotransferase（ ALT）

aspartate aminotransferase（ AST） and total bilirubin（ TBIL） ]and inflammatory factor [tumor necrosis factor-α（ TNF-α）

interleukin-6（ IL-6） and interleukin-8（ IL-8） ] of the two groups were observed before and after treatment. Differences in incidences of complications and scores of quality of life（ QOL） between two groups were compared. RESULTS: There were no statistical significance in differences in operation duration and intraoperative bleeding volume between two groups（ P>0. 05）; the postoperative evacuation time and hospital stay of observation group were significantly shorter than those of the control group

with statistically significant differences（ P<0. 05）. After treatment

the serum AMS levels of both groups were significantly increased

the Cor levels were significantly decreased

the serum AMS and Cor levels of observation group were significantly lower than those of the control group

with statistically significant differences（ P<0. 05）. After treatment

the TBIL

ALT and AST levels of both groups were significantly decreased

and those of the observation group were significantly lower than the control group

with statistically significant differences（ P < 0. 05）. After treatment

the TNF-α

IL-6 and IL-8 levels of both groups were significantly decreased

and those of the observation group were significantly lower than the control group

with statistically significant differences（ P<0. 05）. There were no statistical significance in differences in incidences of biliary stricture

incision infection

residual stone and biliary fistula between two groups（ P>0. 05）. After treatment

the QOL scores of both groups were significantly increased

and that of the observation group was significantly higher than the control group

with statistically significant differences（ P <0. 05）. CONCLUSIONS: The efficacy of phloroglucinol in treatment of gallstone complicated with choledocholithiasis after LTCBDE is remarkable

which can effectively improve patients’ serum AMS and Cor levels

reduce inflammatory factor level

with good safety.