OBJECTIVE: To probe into the clinical efficacy and safety of two different therapeutic regimens（ aspirin combined with clopidogrel

aspirin combined with low-molecular-weight heparin） via random number table in treatment of acute cerebral infarction with posterior circulation arterial stenosis. METHODS: 160 patients who were first attacked by cerebral infarction and diagnosed with acute posterior circulation cerebral infarction were admitted into Affiliated Hospital of the Medical College of Qingdao University from Apr. 2018 to Mar. 2019

which were divided into control group（ aspirin combined with clopidogrel） and treatment group（ aspirin combined with low-molecular-weight heparin） via random number table

with 80 cases in each group. Both groups were assessed for neurological deficits by the National Institutes of Health Stroke Scale（ NIHSS） before treatment and at the 7 th and 14 th days of treatment.Changes of blood coagulation function during medication was observed

and the incidences of related complications such as symptomatic intracranial hemorrhage and systemic organ bleeding during medication were recorded. RESULTS:At the 14 th days of treatment

the FIB

APTT

PT and NIHSS scores of both groups had been significantly improved

with statistically significant differences（ P<0. 05）; at the 14 th day of treatment

the NIHSS score of treatment group was significantly lower than that of the control group

with statistically significant difference（ P < 0. 05）. During medication

the incidences of bleeding events of control group and treatment groups were respectively 2. 50%（ 2/80）and 3. 75%（ 3/80）

the difference had no statistical significance（ P>0. 05）. After treatment

the scores of improved RANKING scale and improved Barthel index scale of treatment group were significantly better than those of the control group

with statistically significant differences（ P<0. 05）. CONCLUSIONS: The efficacy of aspirin combined with lowmolecular-weight heparin in treatment of acute posterior circulation cerebral infarction induced by arterial stenosis is better than that of aspirin combined with clopidogrel

with higher safety.