中西医结合治疗直肠癌术后肠麻痹的有效性与安全性的系统评价

胡启超; 屈彩艳; 曾进浩; 郭耀光; 胡纪可; 李聪; 马骁

doi:10.14009/j.issn.1672-2124.2020.02.004

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中西医结合治疗直肠癌术后肠麻痹的有效性与安全性的系统评价

本期特稿 | 更新时间：2022-10-08

- 中西医结合治疗直肠癌术后肠麻痹的有效性与安全性的系统评价
- Systematic Review of of Efficacy and Safety of Combined Traditional Chinese and Western Medicine in the Treatment of Postoperative Enteroparalysis of Recal Cancer
- 中国医院用药评价与分析 2020年20卷第2期页码：144-148
- 作者机构：
  
  1. 成都中医药大学药学院中药材标准化教育部重点实验室
  2. 成都中医药大学临床医学院
- 作者简介：
- 基金信息：
  
  国家自然科学基金项目（No.81703725）;四川省科技厅应用基础项目（No.2019YJ0492）;成都中医药大学教改建设项目（JGZD201918）;成都中医药大学杏林学者学科人才科研提升计划（No.QNXZ2018025）
- DOI：10.14009/j.issn.1672-2124.2020.02.004
  中图分类号： R735.37
- 纸质出版日期：2020，
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[1]胡启超,屈彩艳,曾进浩,郭耀光,胡纪可,李聪,马骁.中西医结合治疗直肠癌术后肠麻痹的有效性与安全性的系统评价[J].中国医院用药评价与分析,2020,20(02):144-148.

HU Qichao, QU Caiyan, ZENG Jinhao, et al. Systematic Review of of Efficacy and Safety of Combined Traditional Chinese and Western Medicine in the Treatment of Postoperative Enteroparalysis of Recal Cancer[J]. 2020,20(2):144-148.
[1]胡启超,屈彩艳,曾进浩,郭耀光,胡纪可,李聪,马骁.中西医结合治疗直肠癌术后肠麻痹的有效性与安全性的系统评价[J].中国医院用药评价与分析,2020,20(02):144-148. DOI： 10.14009/j.issn.1672-2124.2020.02.004.

HU Qichao, QU Caiyan, ZENG Jinhao, et al. Systematic Review of of Efficacy and Safety of Combined Traditional Chinese and Western Medicine in the Treatment of Postoperative Enteroparalysis of Recal Cancer[J]. 2020,20(2):144-148. DOI： 10.14009/j.issn.1672-2124.2020.02.004.

摘要

目的:采用荟萃分析（Meta分析）方法

系统评价中西医结合治疗直肠癌术后肠麻痹的有效性与安全性。方法:检索中国知网、PubMed、维普数据库、中国生物医学文献数据库和万方等数据库

搜索公开发表的中西医结合治疗直肠癌术后肠麻痹的随机对照试验（观察组患者采用中西医结合治疗

对照组患者单纯采用西医常规治疗）

提取资料并评价文献质量后

采用Rev Man5. 3软件进行Meta分析。结果:共纳入6篇文献

涉及528例患者。Meta分析结果显示

治疗后

观察组患者的治疗有效率明显高于对照组（RR=1. 22

95%CI=1. 13～1. 32

P<0. 000 01）

中医证候积分明显低于对照组（MD=-1. 15

95%CI=-1. 24～-1. 06

P<0. 000 01）

肠鸣音恢复时间（MD=-16. 59

95%CI=-19. 05～-14. 14

P <0. 000 01）、排气恢复时间（MD=-12. 30

95%CI=-13. 07～-11. 52

P <0. 000 01）、排便恢复时间（MD=-14. 17

95%CI=-17. 17～-11. 18

P <0. 000 01）和腹胀消失时间（MD=-1. 13

95%CI=-2. 07～-0. 19

P=0. 02）明显短于对照组

差异均有统计学意义;观察组患者的胃肠减压消失时间短于对照组

但差异无统计学意义（MD=-0. 17

95%CI=-1. 83～-1. 49

P=0. 84）。治疗期间

患者无明显不良反应发生。结论:相对于单纯西医常规治疗

中西医结合治疗直肠癌术后肠麻痹具有更好的疗效。鉴于本研究存在的局限性

期待更多高质量、高水平的临床随机对照试验提供更严谨、可靠的数据。

Abstract

OBJECTIVE: To systematically evaluate the clinical efficacy and safety of combined traditional Chinese and western medicine in the treatment of postoperative enteroparalysis of recal cancer based on Meta-analysis.METHODS: CNKI

PubMed

VIP database

CBM and Wanfang database were retrieved to collect the clinical randomized controlled trial（ RCT） of combined traditional Chinese and western medicine in the treatment of postoperative enteroparalysis of recal cancer（ the observation group was treated with combined traditional Chinese and western medicine

while the control group received western medicine）. After the data were extracted and the quality of the included literature was evaluated

Meta-analysis was conducted by RevMan 5. 3 software. RESULTS: Totally 6 literature were collected

including 528 patients. Meta analysis results showed that the total efficiency of the observation group was significantly higher than that of the control group（ RR = 1. 22

95%CI = 1. 13-1. 32

P<0. 000 01）

and the TCM symptom score was significantly lower than that of the control group（ MD =-1. 15

95% CI =-1. 24--1. 06

P <0. 000 01）

bowel sound recovery time（ MD =-16. 59

95% CI =-19. 05--14. 14

P < 0. 000 01）

recovery time of exhaust（ MD =-12. 30

95%CI =-13. 07--11. 52

P<0. 000 01）

recovery time of defecation（ MD =-14. 17

95%CI =-17. 17--11. 18

P < 0. 000 01） and disappearance time of abdominal distension（ MD =-1. 13

95% CI =-2. 07--0. 19

P = 0. 02） were significantly shorter than those of the control group

with statistically significant differences.The disappearance time of gastrointestinal decompression in the observation group was shorter than that in the control group

but the difference was not statistically significant（ MD =-0. 17

95%CI =-1. 83--1. 49

P = 0. 84）. During the treatment

no obvious adverse drug reactions occurred in both groups. CONCLUSIONS: Compared with conventional western medicine

combined traditional Chinese and western medicine has a better curative effect on postoperative enteroparalysis of rectal cancer. In view of the limitations of this study

more high-quality

high-level randomized controlled trials are expected to provide more rigorous and reliable data.

关键词

中西医结合治疗直肠癌术后肠麻痹Meta分析

Keywords

Combined traditional Chinese and western medicinePostoperative enteroparalysis of recal cancerMeta-analysis

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