OBJECTIVE: To preliminarily explore the mechanism of Qianjiang decoction in the treatment of hypertension based on network pharmacology. METHODS: Traditional Chinese medicine systems pharmacology database and analysis platform（ TCMSP） and CNKI were retrieved to collect 10 kinds of active compounds of traditional Chinese medicine contained in Qianjiang decoction

on this basis

the Compound-Target network was constructed. By means of the therapeutic target database（ TTD）

the targets of hypertension were collected. Compound target network and compound putative target-hypertension target network were applied for protein-protein interaction（ PPI）

gene ontology（ GO） function enrichment analysis and Kyoto encyclopedia of genes and genomes（ KEGG）pathway enrichment analysis. The mechanism of Qianjiang decoction in the treatment of hypertension was explored.RESULTS: A total of 69 Qianjiang decoction compounds

580 predicted targets

658 hypertension-related disease targets and 90 compound-disease targets were obtained. Through PPI analysis

90 target proteins with direct or indirect effects of drugs and diseases were obtained. Totally 22 GO items were significantly enriched in the enrichment analysis

the functions mainly included macromolecule interaction and cell structure composition. Totally 32 KEGG pathways consisted in cancer pathway

renal cell cancer pathway and breast stimulating signal pathway. CONCLUSIONS: This study explored the mechanism of Qianjiang decoction in the treatment of hypertension through the method of network pharmacology and biological information integration analysis. It is preliminarily speculated that the main therapeutic targets are AKT1

SRC and CXCL12

which are related to plasma membrane composition

Janus kinase-signal transduction and activator of transcription（ JAK-STAT） cascade and chemokine signaling pathway

yet the specific mechanism needs to be verified by some experiments.