OBJECTIVE: To systematically evaluate the clinical efficacy of Reduning injection and ribavirin injection respectively in the treatment of children with hand

foot and mouth disease. METHODS: CNKI

Wanfang database

VIP database

PubMed

EMBase and the Cochrane Library were retrieved to collect the randomized controlled trial of Reduning injection and ribavirin injection respectively in the treatment of children with hand

foot and mouth disease（ the control group was treated with ribavirin injection

while the observation group received Reduning injection）. The retrieve time was from the establishment of the database to Feb. 25 th

2019. The Cochrane bias risk assessment tool was used to evaluate the quality of the literature

and the literature containing high-risk items was excluded. The literature that met the inclusion criteria was entered into the RevMan 5. 3 software for Meta-analysis.RESULTS: Totally 27 literature were collected. Meta-analysis results showed that the total effective rate of the observation group was significantly higher than that in the control group（ OR = 7. 12

95% CI = 5. 41-9. 38

P <0. 000 01）

the recovery time of temperature（ MD =-1. 34

95% CI =-2. 24--0. 44

P = 0. 003）

the disappearance time of herpes（ MD =-1. 62

95% CI =-1. 89--1. 34

P < 0. 000 01）

the disappearance time of pharyngeal swelling（ MD=-2. 32

95%CI=-2. 46--2. 18

P<0. 000 01） and the course of disease（ MD=-1. 75

95%CI=-2. 57--0. 92

P<0. 000 01） were significantly shorter than those in the control group

the incidence of adverse drug reactions was significantly lower than that of the control group（ OR = 0. 27

95%CI = 0. 11-0. 67

P = 0. 005）

the above differences were statistically significant. CONCLUSIONS: Retonin injection is better than ribavirin injection in the treatment of children with hand

foot and mouth disease in improving clinical total effective rate

improving the clinical symptoms

shortening the course of disease and safety of medication.