OBJECTIVE: To probe into the efficacy of motherwort injection combined with bilateral ascending ligation of uterine artery on refractory postpartum hemorrhage and its effects on ovarian function. METHODS: Totally 130 patients underwent cesarean section and diagnosed with refractory postpartum hemorrhage admitted into Qinhuangdao Cerebrovasculra Disease Hospital from Sept. 2015 to Jan. 2019 were extracted to be divided into the control group and the study group via the random number table

with 65 cases in each group. The control group was treated with bilateral ascending ligation of uterine artery

while the study group received motherwort injection bases on the control group. Hemostasis effects

hysterectomy and puerperal fever

peripheral blood coagulation function indicators [prothrombin time（ PT）

partial thromboplastin time（ APTT）

fibrinogen（ FIB）

fibrinogen degradation products（ FDP） and D-dimer（ D-D） ] and ovarian function indicators [estradiol（ E2）

luteinizing hormone（ LH）and follicle stimulating hormone（ FSH） ]

levels of two groups were observed. And the adverse drug reactions induced by motherwort injection were analyzed. RESULTS: There was no significant difference in intraoperative blood loss between two groups（ P

>

0. 05）. The amount of bleeding at 24 h and the volume of intrauterine hemorrhage at 2 weeks in the study group were significantly less than those in the control group

the height of the uterine fundus was significantly lower than that of the control group at 3 d after surgery

the duration of lochia rubra was significantly shorter than that of the control group

with statistically significant differences（ P

<

0. 05）. There was no significant difference in the hysterectomy rate between two groups（ P

>

0. 05）. The incidence of puerperal fever in the study group was 32. 31%（ 21/65）

significantly lower than that in the control group（ 70. 77%

46/65）

and the difference was statistically significant（ P

<

0. 05）. After hemostasis of 3 d

the levels of PT

APTT

FIB

FDP and D-D in the observation group were significantly lower than those in the control group; after hemostasis of 3 months

the level of E

2

in the observation group was significantly higher than that in the control group

and the levels of LH and FSH were significantly lower than those in the control group

and the differences were statistically significant（ P

<

0. 05）. No severe adverse drug reactions induced by motherwort injection were observed during the observation period.CONCLUSIONS: Motherwort injection combined with bilateral ascending ligation of uterine artery on refractory postpartum hemorrhage can improve the hemostatic effects

optimize the coagulation function

and has a positive role in protecting ovarian function.