OBJECTIVE: To probe into the effects of berberine hydrochloride combined with bifidobacterium quadruple bacteria on infantile infectious diarrhea and its influence on intestinal flora. METHODS: Totally 150 patients with infectious diarrhea admitted into Hexian Memorial Hospital Affiliated to Southern Medical University from Jan.2018 to Jan. 2019 were extracted to be divided into the berberine hydrochloride group（ treated with berberine hydrochloride alone）

bifidobacterium quadruple bacteria group（ treated with bifidobacterium quadruple bacteria alone）

and combined group（ treated with berberine hydrochloride combined with bifidobacterium quadruple bacteria）via the random number table

with 50 cases in each group. The clinical efficacy

results of intestinal flora determination and differences of serum albumin levels of three groups were compared. RESULTS: The total effective rates of the combined group

berberine hydrochloride group and bifidobacterium quadruple bacteria group were respectively 98. 00%（ 49/50）

84. 00%（ 42/50） and 86. 00%（ 43/50）

the total effective rates in combined group were significantly higher than that in the berberine hydrochloride group and the bifidobacterium quadruple bacteria group

with significant differences（ P<0. 05）. After treatment

the results of intestinal flora and serum albumin levels in combined group were significantly better than those in the berberine hydrochloride group and the bifidobacterium quadruple bacteria group

with significant differences（ P < 0. 05）. CONCLUSIONS: The treatment of intestinal infectious diarrhea with berberine hydrochloride and bifidobacterium quadruple bacteria can achieve certain effects

but the combined effects of the two drugs are better.